Business Wire

CorFlow Presents Fundamental New Insights into the Coronary Microcirculation at ACC


CorFlow Therapeutics AG ( today announced that the company will present fundamental new insights into the coronary microcirculation during the annual meeting of the American College of Cardiology (ACC) in Orlando, FL, March 10-12, 2018.

CorFlow has since its foundation in June 2016 worked to document that the Controlled Flow Infusion (CoFITM) technology is able to measure the coronary microvascular status and provide therapy to the compromised coronary microcirculation at the same time. Microvascular obstruction (MVO) affects more than half of the acute heart attack patients and is an independent predictor for complications including heart failure which constitutes a high cost burden for the world-wide health care system. To address this large unmet medical need in interventional cardiology, CorFlow has developed an in-vivo model which reproducibly creates MVO in an occlusion-reperfusion model with very low complication rates. Using this in-vivo model, the CoFITM technology was used to measure real-time dynamic microvascular resistance (dMVR) in the coronary circulation and these dMVR values were correlated to post-procedure contrast enhanced magnetic resonance imaging (MRI) and histology. A correlation between the procedural CoFITM dMVR values and post-procedural MRI will enable treatment of MVO before the patients leave the cathlab and potentially reduce the complication rates for severe heart attack patients.

In a comment, Dr. Renu Virmani, an internationally renowned cardiovascular pathologist and co-author of the histology poster, stated: "These findings suggest that the fundamental effects of a human heart attack have to be reconsidered. Our findings show that MVO in acute heart attacks can be created without the presence of thrombi. The results furthermore show that minute reductions in coronary volume flow causes an exponential collapse of the coronary microcirculation and that epicardial revascularization alone is not sufficient to open the collapsed coronary microcirculation. If these findings hold true in our upcoming investigations, we will have to fundamentally rethink the comprehensive treatment of an acute heart attack with attention to the microvasculature as well as the major epicardial vessels."

Jon H. Hoem, CorFlow's CEO and co-Founder, commented: "We are very pleased that our in-vivo results have been accepted for publication during the important ACC conference and look forward to discuss these results with cardiologists attending the conference."

The data from the CorFlow non-clinical trials will be used in the upcoming submissions for the CorFlow MOCA I (MVO with CoFI™ System Assessment I) First-in-Man clinical trial.

Contact information

CorFlow Therapeutics AG
Jon H. Hoem, +41 79 606 2 902

Om Business Wire

Business Wire
Business Wire
24 Martin Lane
EC4R 0DR London

+44 20 7626 1982

(c) 2018 Business Wire, Inc., All rights reserved.

Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.

Følg saker fra Business Wire

Registrer deg med din epostadresse under for å få de nyeste sakene fra Business Wire på epost fortløpende. Du kan melde deg av når som helst.

Siste saker fra Business Wire

NTT Communications' SD-WAN Gives McLaren Racing an Edge for 2018 Season22.3.2018 06:00Pressemelding

McLaren Formula 1 TEAM (McLaren), a pioneering leader in Formula 1 motor racing for more than 50 years, and NTT Communications Corporation (NTT Com), the ICT solutions and international communications business within the NTT Group (TOKYO:9432), announced today that McLaren will adopt SD-WAN (software-defined wide-area network) technology from NTT Com to connect the McLaren Technology Centre with racing circuits in 21 countries during the 2018 season. The decision follows a successful test deployment of the technology during the 2017 Japan Grand Prix, when McLaren was able to send 100GB of data during a race from Japan to the UK via NTT Com’s SD-WAN. NTT Com’s SD-WAN uses software to control the WAN, providing McLaren with quick, secure, reliable and flexible management of data traffic flows. A variety of traffic can be sent via different connections, such as internet, mobile and MPLS, depending on time, priority and current network speed. This flexibility allows the priority routing of

Home to the Cloud: e-shelter Continues to Expand and Announces It Will Open Another Data Center Campus in Frankfurt in Early 201922.3.2018 02:06Pressemelding

e-shelter, a leading data center provider in Europe and an NTT Communications Group Company, has today announced the acquisition of new development site in Frankfurt, which will be its 4th location in the city. This press release features multimedia. View the full release here: The expansion comes on the back of strong customer demand in Frankfurt, as market leader, e-shelter already operates 3 sites across the city, including Europe’s largest data center campus, Frankfurt 1. The “Frankfurt 4 Data Center” campus is located in Hattersheim in the west of the city and will feature 5 DC buildings built out in phases, with the first building of 9.7MW IT load scheduled to open in early 2019. Once fully built out, the site is capable of housing up to 60MW IT load and 24,000 sqm of IT space, supporting an average power density of 2.5 kW/sqm. The new facility will follow e-shelter’s successful business model – offering both wholesale and

Digi Communications N.V.: Convocation of the Company’s General Shareholders Meeting for 2 May 2018 for the Approval of, among Others, the 2017 Annual Report and of the 2017 Financial Statements21.3.2018 19:05Pressemelding

The Company would like to inform the market and its investors that today, 21 March 2018, the Board of Directors of the Company convenes the general shareholders meeting of the shareholders (the “GSM”) of the Company (Digi Communications N.V.), to be held on Wednesday, 2 May 2018 at 12:00 p.m. CEST, at Radisson Blu Hotel Amsterdam airport, Boeing avenue 2, 1119 PB Schiphol-Rrijk, The Netherlands. The main topics for the GSM are the following: discussion and approval items on the Annual Report 2017 (including the annual report, the financial statements (consolidated and stand-alone) and the auditor report); appointment of the statutory auditor for the year ending 31 December 2018; approval for the distribution of a gross dividend of 0.35 RON per share; ex-date – 21 May 2018, reference date – 22 May 2018, and the payment date – 29 May 2018; designation of the Board of Directors as the competent body to repurchase own Class B Shares; approval of award of stock options and shares to executi

Pandora to Acquire Leading Digital Audio Ad Tech Firm AdsWizz21.3.2018 13:00Pressemelding

Pandora (NYSE: P), the largest music streaming service in the U.S., today announced it will acquire AdsWizz, the global leader in digital audio ad technology. The addition of AdsWizz will upgrade Pandora’s ad tech capabilities, provide its advertisers with greater audience reach, and expand the company’s revenue opportunities. AdsWizz is one of the few ad tech firms that is completely dedicated to digital audio, serving some of the largest players in the industry. With digital audio advertising growing 42% year-over-year, according to the IAB, the combined offering of Pandora and AdsWizz will capitalize on this trend, while making it easier for publishers to monetize their inventory, and for advertisers to buy and measure their campaigns. “Since I joined Pandora six months ago, I have highlighted ad tech as a key area of investment for us. Today we took an important step to advance that priority and accelerate our product roadmap,” said Roger Lynch, CEO of Pandora. “With our scale in a

Fintech Entrepreneur and myPOS Founder Christo Georgiev Reveals Plans to Set Up a Chain of myPOS Stores across Europe21.3.2018 12:51Pressemelding

Founder of myPOS, Christo Georgiev announces plans to open myPOS flagship stores across Europe in an effort to bring the service closer to its customers. Designed for small and mid-sized businesses, myPOS offers affordable payment acceptance tools, winning the trust of over 40,000 enterprises across the EEA & Switzerland. This press release features multimedia. View the full release here: An interior view of the myPOS London Store (Photo: Business Wire) Until now, the operational framework of myPOS included a network of promoters in almost every European country and an online store, owned and operated by myPOS. The next logical step was to sell through physical stores. On 8th February 2018, myPOS opened doors to its first flagship store, located on 36 Knightsbridge, London and marked the beginning of a new era for myPOS. Soon after, plans were revealed for other openings in Europe with another location coming up on 5th April 201

AI Expo Europe: The leading Artificial Intelligence Event to Arrive in the European Capital of Innovation, Amsterdam21.3.2018 12:47Pressemelding

The AI Expo Europe is set to arrive in the hub of AI innovation, Amsterdam, The Netherlands, this Summer (27-28th June) with an aim of ‘delivering AI for a smarter future.’ The well-connected Dutch capital is known for its unique, rich culture and canal-side views and was even awarded the European Capital of Innovation in 2016 by the European Commission. The city’s AI scene is thriving with the arrival of a world-class artificial intelligence hub by early 2021 and venture capitalist investment. The AI hub will be created in collaboration with the University of Amsterdam (UvA) and the City of Amsterdam at the Amsterdam Science Park, a place where education, research and entrepreneurship will come together as one. Geert ten Dam, president of the UvA’s Executive Board stated that: “Amsterdam is widely recognised both in the Netherlands and abroad for its leading scientific expertise in the area of AI…” This press release features multimedia. View the full release here: https://www.busines