ProLynx announces allowance of additional U.S. patent for PLX038, a novel DNA damage response enhancer
SAN FRANCISCO, April 10, 2018 (GLOBE NEWSWIRE) -- Prolynx LLC (San Francisco, CA) announced it received a Notice of Allowance for its DNA damage enhancer PLX038 (PEG~SN-38), currently in Phase 1 trials at MD Anderson. PLX038 is a prodrug of SN-38, the active metabolite of the anti-cancer agent Irinotecan, which inhibits Topoisomerase 1 (Topo 1) during DNA replication and causes replication stress and DNA damage. The new allowed claims expand ProLynx's broad patent coverage of PEG~SN-38 conjugates using ProLynx beta-eliminative linkers in US Patent 8,754,19.
DNA damaging agents, such as PLX038, have assumed a new importance in the context of the DNA damage response (DDR) and synthetic lethality. To combat threats posed by DNA damage, cells have mechanisms to signal the presence of DNA damage and promote its repair - collectively termed the DNA-damage response. Cells defective in DDR - as in many tumors - display heightened sensitivity towards DNA-damaging agents such as Topo 1 inhibitors. Such agents can increase DNA damage to a level that is tolerable to normal cells but lethal to cancer cells with DDR deficiencies. Hence, an effective Topo 1 inhibitor will enhance DNA damage and death of cells with DDR defects - such as cells deficient in DNA repair proteins BRCA, ATM or ATR - or in cells treated with inhibitors of DDR components - such as PARP, ATM or ATR inhibitors.
ProLynx's PLX038 slowly releases SN-38 such that tumors are exposed to the DNA-damaging agent SN-38 for long periods. In addition, the nanomolecule accumulates and remains in tumors for long periods, slowly releasing the drug at high intra-tumoral concentrations.
ProLynx's PEG~SN-38 conjugates show remarkable antitumor effects in mouse models of human tumors with DDR defects and those treated with DDR inhibitors. For example, in the BRCA1 human xenograft MX-1, a single, non-toxic dose completely inhibited tumor growth and resolved massive tumors. Likewise, a combination of low dose PEG~SN-38 with a PARP inhibitor completely inhibited tumor growth, and shrank large tumors. Moreover, a low dose of PEG~SN-38 followed by a period to allow tumor accumulation and systemic elimination sensitized the tumor such that treatment with a low dose of PARP inhibitor completely inhibited tumor growth.
Daniel Santi, cofounder and President of ProLynx, said, "PLX038 may provide a general agent for enhancing the selective killing of cancer cells with certain DDR defects. In addition, PLX038 seems to enhance the effects of other inhibitors that act on DDR components by synthetic lethality, suggesting that it may be used in combination with such agents."
About ProLynx: ProLynx LLC is a privately held biotechnology company located in San Francisco, CA, developing delivery systems for half-life extension of small molecules, peptides and proteins. The company applies its technology to extend half-lives of new drug candidates, and to improve properties of off-patent therapeutics. ProLynx has a monthly GLP-1 receptor agonist in its pre-clinical portfolio, and PLX038 in Phase 1 clinical trials. Further information about the company may be found at www.ProLynxllc.com.
Daniel.V.Santi@gmail.com 415-552-5306 or email@example.com 805-558-0361
The issuer of this announcement warrants that they are solely responsible for the content, accuracy and originality of the information contained therein.
Source: ProLynx LLC via Globenewswire
Om Nasdaq GlobeNewswire
One Liberty Plaza - 165 Broadway
NY 10006 New York
+1 212 401 8700http://www.nasdaqomx.com
NASDAQ (NASDAQ: NDAQ) is a leading provider of trading, exchange technology, information and public company services across six continents.
Følg saker fra Nasdaq GlobeNewswire
Registrer deg med din epostadresse under for å få de nyeste sakene fra Nasdaq GlobeNewswire på epost fortløpende. Du kan melde deg av når som helst.
Siste saker fra Nasdaq GlobeNewswire
Tenaris Announces 2018 First Quarter Results26.4.2018 23:02 | Pressemelding
Tenaris S.A. / Tenaris Announces 2018 First Quarter Results . Processed and transmitted by Nasdaq Corporate Solutions. The issuer is solely responsible for the content of this announcement. The financial and operational information contained in this press release is based on unaudited consolidated condensed interim financial statements presented in U.S. dollars and prepared in accordance with International Financial Reporting Standards ("IFRS") as issued by the International Accounting Standard Board ("IASB") and in conformity with IFRS as adopted by the European Union ("EU"). Additionally, this press release includes non-IFRS alternative performance measures i.e., EBITDA, Net cash / debt and Free Cash Flow. See exhibit I for more details on these alternative performance measures. LUXEMBOURG, April 26, 2018 (GLOBE NEWSWIRE) -- Tenaris S.A. (NYSE:TS) (BAE:TS) (BMV:TS) (MILAN:TEN) ("Tenaris") today announced its results for the quarter ended March 31, 2018 in comparison with its results
Atico Produces 5.48 Million Pounds of Cu and 2,825 Ounces of Au in First Quarter 201826.4.2018 22:35 | Pressemelding
VANCOUVER, British Columbia, April 26, 2018 (GLOBE NEWSWIRE) -- Atico Mining Corporation (the "Company" or "Atico") (TSX-V:ATY) (OTC:ATCMF) announces its operating results for the three months ended March 31, 2018 from its El Roble mine. Production for the quarter totaled 5.48 million pounds of copper and 2,825 ounces of gold in concentrates, an increase of 9% and 11% for copper and gold, respectively, over the same period in 2017. "We are very pleased to report our strongest operating quarter to date while maintaining steady state production levels and a robust start towards our 2018 operational objectives" said Fernando E. Ganoza, CEO. "For the remainder of the year, the Company will continue focusing on the regional and mine vicinity exploration programs with rigs currently drilling on surface and underground." First Quarter Operational Highlights Production of 5.48 million pounds of copper contained in concentrates; an increase of 9% over Q1 2017. Production of 2,825 ounces of gold
Cloudflare Grows Network by Nearly 30 Percent in First Quarter26.4.2018 22:00 | Pressemelding
The company announced three new products and a major collaboration as part of giant quarter SAN FRANCISCO, April 26, 2018 (GLOBE NEWSWIRE) -- Cloudflare, the leading Internet performance and security company, today announced record network growth in the first quarter of 2018. The company added 32 new cities, growing its network to 151 points of presence globally. Cloudflare now protects more than 8 million domains, websites, APIs, mobile applications, and anything connected to the Internet. "At Cloudflare's core is its network, which we've built to be flexible, efficient, and able to perform any task in any given location," said Matthew Prince, co-founder and CEO of Cloudflare. "In this last quarter, we grew our network at record pace, bringing our network closer to everyone on earth. This means that we're able to roll out products at a global scale for users everywhere." Today's announcement caps off a strong quarter for Cloudflare. The company announced three major new products in th
VITEC's EZ TV Video Wall Solution Wins Best of Show Award at the 2018 NAB Show26.4.2018 19:00 | Pressemelding
VITEC's EZ TV Video Wall Solution Wins Best of Show Award at the 2018 NAB Show SUNNYVALE, Calif., April 26, 2018 (GLOBE NEWSWIRE) -- VITEC, a worldwide leader in advanced video encoding and streaming solutions, today announced that the new EZ TV video wall processor, available within the award-winning EZ TV IPTV and Digital Signage Platform, was recognized with a Best of Show Award at the 2018 NAB Show from Sound & Video Contractor (SVC) magazine. Evaluated by a panel of industry experts, the Best of Show Award winners were selected based on innovation, feature set, cost efficiency, and performance in serving the industry. VITEC's video wall solution is designed to simplify deployment and management of projects involving IPTV, digital signage, and video wall content, while delivering a breathtaking visual experience. The new EZ TV video wall processors are 100 percent hardware-based, feature low-latency native playback of IPTV streams up to 4K, and support interactive content, video, a
Inspiration in Receipt of Crypto Currency Proposal26.4.2018 16:54 | Pressemelding
TORONTO, April 26, 2018 (GLOBE NEWSWIRE) -- Inspiration Mining Corporation ("Inspiration" or the "Corporation") (CSE:ISM) is pleased to announce that it is contemplating upon the request of Compassion Cannabis that it is allowed to accept crypto currency for settlement for any transactions that occur. The logic is that it would make for easy settlement in any jurisdiction. The Company is not adverse to this proposal, but must perform its due diligence and will table the matter at the AGM. Compassion Cannabis is an Ontario Corp., which has expertise to forward various facets of the explosive new market of the marijuana industry, including but not limited to the "Vape" market and dispensary centers for the industry. We believe this will be an extremely lucrative space with tremendous demand in the medical cannabis industry. For further information, please contact Randy Miller, Chief Executive Officer of the Corporation, at tel: 416-842-9000, www.inspirationmining.com The CSE has not revi
SNOMED International Announces Brazil as its 33rd Member26.4.2018 15:12 | Pressemelding
London, United Kingdom, April 26, 2018 (GLOBE NEWSWIRE) -- Brazil's Ministry of Health and SNOMED International announce that as of April 1, 2018, Brazil has joined the organization as SNOMED International's thirty-third Member. With SNOMED CT already used in various parts of the country, Brazil joined SNOMED International to support nationwide health system transformation as a foundational element of its ehealth Strategy, digiSUS. As outlined in this national strategy, the SUS Monitoring and Evaluation Department of Brazil's Ministry of Health is responsible overall for governance of the National Electronic Health Strategy and its related evaluation and development. Demonstrated through its membership in SNOMED International, Brazil has defined SNOMED CT as the chosen international reference terminology for use in its clinical systems supporting the national ehealth strategy. SNOMED CT is the world's most comprehensive health terminology. Founded in 2007 by nine charter nations, SNOME
I vårt presserom finner du alle våre siste saker, kontaktpersoner, bilder, dokumenter og annen relevant informasjon om oss.Besøk vårt presserom