ProLynx and Daiichi Sankyo announce the development of technology for half-life extension of small molecules in the eye
SAN FRANCISCO, Aug. 29, 2018 (GLOBE NEWSWIRE) -- ProLynx and Daiichi Sankyo Company, Limited, announced today the publication of a paper in the journal TVST entitled “A controlled release system for long-acting intravitreal delivery of small molecules”. In this work, they described a technology to extend the intravitreal half-life of small molecule drugs to rival the intravitreal half-lives of macromolecules such as antibodies and PEGylated aptamers.
Intravitreal (IVT) injection is an important drug delivery modality for many diseases of the eye. IVT injection minimizes systemic exposure and allows intraocular drug exposures not otherwise achievable. However, because IVT therapy is an invasive procedure that often requires long-term serial injections, IVT drugs require long IVT half-lives and dosing intervals.
In the past, IVT injections of small molecule therapeutics have been impractical for treatment of chronic eye diseases because they have short half-lives in the vitreous and require frequent injections. In the present work a small molecule drug was attached to a nanomolecular 40kDa PEG via a cleavable linker. The large nanomolecule maintains the small molecule in the vitreous for long periods, and the attached drug is slowly released by a self-cleaving linker. Using this approach, the half-life of a small molecule complement factor D inhibitor in the rabbit eye was prolonged 10-fold. It was posited that the technology could maintain a small molecule drug in the human vitreous for periods comparable to macromolecular drugs, requiring intravitreal injections at about one month intervals.
Daniel Santi, co-founder and President of ProLynx, stated “This study reports an entirely new approach for increasing the intravitreal half-lives of small molecule therapeutics; a potent small molecule with an appropriate therapeutic window should be administrable by intravitreal injections in the human at once-monthly intervals.”
About ProLynx: ProLynx LLC is a privately held biotechnology company located in San Francisco, CA, developing proprietary controlled release systems for long-acting delivery of small molecules, peptides and proteins. The company applies its technology to extend half-lives and improve properties of the drug candidates of pharmaceutical companies as well as to enhance properties of off-patent therapeutics. ProLynx has a monthly GLP-1 receptor agonist and a subcutaneous long-acting octreotide in its pre-clinical portfolio, and a DNA-damage response enhancer, PEG~SN-38, in Phase 1 clinical trials. For more information, please visit: www.ProLynxllc.com.
About Daiichi Sankyo: Daiichi Sankyo is dedicated to the creation and supply of innovative pharmaceutical products to address unmet medical needs of patients. With over 100 years of scientific expertise and a presence in more than 20 countries, Daiichi Sankyo draws upon a rich legacy of innovation and a robust pipeline of new medicines. In addition to a strong portfolio of medicines for hypertension and thrombotic disorders, Daiichi Sankyo research and development is focused on bringing forth novel therapies in oncology, and new horizon areas such as pain management, neurodegenerative diseases, heart and kidney diseases, and rare diseases. For more information, please visit: www.daiichisankyo.com.
BD@ProLynxllc.com or email@example.com 805-558-0361
Om Nasdaq GlobeNewswire
One Liberty Plaza - 165 Broadway
NY 10006 New York
+1 212 401 8700http://www.nasdaqomx.com
NASDAQ (NASDAQ: NDAQ) is a leading provider of trading, exchange technology, information and public company services across six continents.
Følg saker fra Nasdaq GlobeNewswire
Registrer deg med din epostadresse under for å få de nyeste sakene fra Nasdaq GlobeNewswire på epost fortløpende. Du kan melde deg av når som helst.
Siste saker fra Nasdaq GlobeNewswire
ERYTECH Announces Enrollment of First Patients in Phase 3 Clinical Trial Evaluating Eryaspase for the Treatment of Second Line Pancreatic Cancer20.9.2018 07:30 | Pressemelding
LYON, France and CAMBRIDGE, Mass., Sept. 20, 2018 (GLOBE NEWSWIRE) -- ERYTECH Pharma (Euronext Paris: ERYP - Nasdaq: ERYP), a clinical-stage biopharmaceutical company developing innovative therapies by encapsulating drug substances inside red blood cells, today announced that the first three patients have been enrolled in its pivotal Phase 3 clinical trial, named ‘TRYbeCA1’, evaluating its lead product candidate eryaspase for the treatment of second line metastatic pancreatic cancer. The TRYbeCa1 (NCT03665441) trial will enroll approximately 500 patients with second line metastatic pancreatic cancer in 120-130 clinical sites in Europe and the US. Patients who meet the eligibility criteria are randomized 1-to-1 to receive eryaspase in combination with standard chemotherapy (gemcitabine/abraxane or irinotecan -based regimen) or chemotherapy alone until disease progression. The primary endpoint is overall survival. An interim analysis is foreseen when approximately two-thirds of events ha
NEP GROUP RECOGNIZED AT THREE AWARDS SHOWS DURING IBC 201819.9.2018 16:17 | Pressemelding
Leading Outsourced Technical Production Partner Takes Home Top Honors at the SVG Europe Sport Production Awards, and was a Finalist for an IABM BaM™ Award 2018 and Two IBC2018 Innovation Awards PITTSBURGH and AMSTERDAM, Sept. 19, 2018 (GLOBE NEWSWIRE) -- NEP Group is thrilled to announce today that the company received recognition for their leading innovations, along with their client partners, at this year’s IBC Show. NEP The Netherlands’ Remote Commentary solution won the SVG Europe Sport Production Award for Outstanding Technical Achievement, Audio and was a finalist for an IABM BaM™ Award award for Project, Collaboration or Event. NEP’s Mediabank product was a finalist for an IBC2018 Innovation award for Content Distribution and NEP Finland was a finalist in the Content Everywhere category. “At NEP, one of our core values is client-driven innovation, and we are entirely committed to developing new technology that solves real-world challenges and delivers exceptional results. It’s w
Panini Hires Dan Napoles as Senior Vice President, Global Technical Services19.9.2018 14:36 | Pressemelding
Addition to Panini Executive Leadership Team DAYTON, Ohio, Sept. 19, 2018 (GLOBE NEWSWIRE) -- Panini is pleased to announce that effective September 17, 2018, Dan Napoles joined the company as Senior Vice President, Global Technical Services (GTS) and will lead the company’s technical services functions worldwide including services delivery, services program definition & development, GTS commercial results & operational excellence, and GTS strategic direction & growth. Napoles will be instrumental to Panini’s strategy to support continued growth while extending its market leadership position. Mr. Napoles comes to Panini after a highly successful career in services with Avery Dennison, a $6.6 billion global materials science and manufacturing company with operations in more than 50 countries. During his tenure with Avery Dennison, Dan started as a field engineer in Los Angeles CA, servicing printers and radio frequency security systems, including system installation and contract sales r
Flashpoint Global Channel Program Welcomes New Talent to Accelerate Growth in EMEA Region19.9.2018 12:00 | Pressemelding
Appointment of Industry Veteran Reinforces Company’s Commitment to Partnerships, International Expansion NEW YORK, Sept. 19, 2018 (GLOBE NEWSWIRE) -- Flashpoint, the global leader in Business Risk Intelligence (BRI), today announced that industry veteran Roy Pickard has joined the company as channel sales manager for Europe, the Middle East and Africa (EMEA). His appointment as the first EMEA-based member of the Flashpoint Global Channel Program (GCP) team marks the latest international milestone for the company, following its successful expansion in Asia Pacific and Latin America earlier this year. Pickard brings more than two decades of experience forging lasting partnerships and strengthening channel portfolios at esteemed security and technology enterprises including Resolve Systems, Tufin, Carbon Black, FireEye, Safenet Inc., and TrendMicro. At Flashpoint, he will lead recruitment, development, and enablement initiatives for channel partners throughout EMEA. Given the immense size
FOUR IN FIVE EXECUTIVES AGREE AGILITY IS MOST IMPORTANT CHARACTERISTIC OF A SUCCESSFUL ORGANIZATION18.9.2018 16:03 | Pressemelding
New research by Forbes Insights and sponsored by Scrum Alliance brings light to the “elusive” Agile enterprise Denver Colorado, Sept. 18, 2018 (GLOBE NEWSWIRE) -- PRESS RELEASE FOR IMMEDIATE RELEASE: MEDIA CONTACT: September 18, 2018 Heather Leigh, Public Relations Director 720-443-7314,firstname.lastname@example.org www.scrumalliance.org SEPTEMBER 18, 2018 – DENVER, CO – A new report by Forbes Insights finds 81 percent of respondents agree on the critical importance of agility when it comes to leading a successful organization. The report, “The Elusive Agile Enterprise,” was sponsored by Scrum Alliance, a Scrum certifying body and the largest professional association of Agile practitioners worldwide. In preparing the report, the Forbes Insights team surveyed more than 1,000 C-level executives worldwide, and also conducted one-on-one interviews with leaders of select “champion” organizations, including GEHealthcare, J. Walter Thompson Company, Nokia, Team WIKISPEED, Toyota Connected and Unis
Cloudian Joins iRODS Consortium18.9.2018 15:00 | Pressemelding
HyperStore Enterprise Object Storage Validated with iRODS Platform SAN MATEO, Calif., Sept. 18, 2018 (GLOBE NEWSWIRE) -- Cloudian today announced the company has joined the iRODS Consortium, the foundation that leads development and support of the integrated Rule-Oriented Data System (iRODS). Testing for HyperStore enterprise object storage with iRODS is complete, and users may now deploy the combined solution where local workflows require cost-effective, exabyte-scalable storage and ease of integration. iRODS is free open source software for data discovery, workflow automation, secure collaboration and data virtualization used by research and business organizations around the globe. Easily deployed in an existing infrastructure, iRODS creates a unified namespace and a metadata catalog of all the data and users within the storage environment. With the iRODS rule engine framework, users can completely automate an organization’s data management policy. “We’re thrilled to be working with
I vårt presserom finner du alle våre siste saker, kontaktpersoner, bilder, dokumenter og annen relevant informasjon om oss.Besøk vårt presserom