GlobeNewswire

Paper in Scientific Reports Highlights Ability of 4D Pharma’s MRx0004 to Protect Against Airway Inflammation in Severe Asthma

Del
  • Data suggest that MRx0004 is a promising next-generation therapeutic for management of asthma

LEEDS, United Kingdom, Aug. 14, 2018 (GLOBE NEWSWIRE) -- 4D pharma plc (AIM: DDDD), a pharmaceutical company leading the development of live biotherapeutics, today announces the publication of a paper demonstrating that MRx0004, a live biotherapeutic derived from the human gut microbiome, can protect against airway inflammation by reducing both neutrophilic and eosinophilic infiltration in a mouse model of severe asthma.

The paper “Bifidobacterium breve MRx0004 protects against airway inflammation in a severe asthma model by suppressing both neutrophil and eosinophil lung infiltration” (Raftis et al.) is published in the Nature Publishing Group journal Scientific Reports .

Asthma is a phenotypically heterogeneous disease.  Between 5-10 % of asthma patients have a severe form of the disease which is refractory to steroid treatment and whose symptoms cannot be controlled despite the application of high-intensity treatments.  In severe asthma, airway inflammation can be predominantly eosinophilic, neutrophilic, or mixed and patients presenting with neutrophilic inflammation have particularly poor treatment options.  Severe asthma is estimated to account for more than 60% of asthma-associated healthcare costs.

MRx0004 is a strain of Bifidobacterium breve isolated from the gut microbiome of a healthy human.  It was tested prophylactically and therapeutically in a house dust mite mouse model of severe asthma.  A strong reduction of neutrophil and eosinophil infiltration was observed in lung bronchoalveolar lavage fluid (BALF) following MRx0004 treatment.  Furthermore, MRx0004 had a striking effect on lung histopathology, with a strong reduction of both peribronchiolar and perivascular inflammatory infiltrate. The efficacy of MRx0004 exceeded that of the anti-IL-17 positive control used in the experiment.

4D pharma Chief Scientific Officer, Alex Stevenson, commented, “These data provide further evidence that live biotherapeutics have the potential to change the way we treat disease.  Using MRx0004, we have demonstrated superior efficacy to biologics in a severe and steroid-resistant model of asthma.”

He added, “Perhaps more significantly, we have shown that MRx0004 can strongly reduce neutrophil and eosinophil airway infiltration concurrently.  This is something which is not achievable with current therapies and is further evidence of the potential of MRx0004 as a next-generation therapeutic for the management of asthma.”

For further information please contact:

4D + 44 (0)113 895 0130
Duncan Peyton, Chief Executive Officer  
   
Zeus Capital Limited - Nomad and Joint Broker  
Dan Bate / Jordan Warburton +44 (0) 161 831 1512
   
Bryan Garnier & Co. Limited - Joint Broker +44 (0)20 7332 2500
Dominic Wilson
Phil Walker
 

About 4D
Founded in February 2014, 4D is a world leader in the development of live biotherapeutics, a novel and emerging class of drugs, defined by the FDA as biological products that contain a live organism, such as a bacteria, that is applicable to the prevention, treatment or cure of a disease.  4D has developed a proprietary platform that rationally identifies novel bacteria that have a precise and evolved therapeutic effect.  All of 4D's live biotherapeutic products are orally delivered single strains of bacteria that are naturally found in the healthy human gut.  4D has completed a phase I study in Irritable Bowel Syndrome and has completed dosing in a phase I study in Paediatric Crohn's Disease.  It currently has a pipeline of 13 pre-clinical programmes, covering disease areas such as cancer, poorly controlled asthma, autoimmune and CNS disease, and plans to commence four additional clinical studies in 2018. For more information, refer to https://www.4dpharmaplc.com/.

Om GlobeNewswire

GlobeNewswire
GlobeNewswire
One Liberty Plaza - 165 Broadway
NY 10006 New York

https://globenewswire.com

GlobeNewswire is one of the world's largest newswire distribution networks, specializing in the delivery of corporate press releases financial disclosures and multimedia content to the media, investment community, individual investors and the general public.

Følg saker fra GlobeNewswire

Registrer deg med din epostadresse under for å få de nyeste sakene fra GlobeNewswire på epost fortløpende. Du kan melde deg av når som helst.

Siste saker fra GlobeNewswire

iGrafx Announces Cohesive RPA Accelerator Solution23.4.2019 14:48:00 CESTPressemelding

Combines Core Capabilities from iGrafx, myInvenio, Servicetrace, UiPath and BP3 Global Dallas, TX, April 23, 2019 (GLOBE NEWSWIRE) -- Today at the iNNOVATE 2019 conference, iGrafx unveiled the industry’s first end-to-end RPA Accelerator solution, enabling enterprises to identify, assess, prioritize, execute and govern robotic process automation (RPA) projects. The turnkey package includes a new version of the iGrafx Platform, along with process mining from myInvenio, RPA bots from either UiPath or Servicetrace and professional services from BP3. For the first time ever, Center of Excellence leaders can access the combined, best-of-breed capabilities from a single source for a single price. “Our customers tell us that they have a huge challenge understanding what to optimize and automate in order to achieve real digital transformation,” said Ryan Tognazzini, CEO at iGrafx. This is a challenge that is also iterated again and again by industry experts. In a recent Forrester report, Rob Ko

MJBizDaily Introduces MJBizDaily European Cannabis Symposium, Copenhagen, Denmark, May 623.4.2019 11:00:00 CESTPressemelding

DENVER, April 23, 2019 (GLOBE NEWSWIRE) -- The producers of America’s oldest and largest cannabis trade show, Marijuana Business Conference & Expo (MJBizCon), introduce MJBizDaily’s European Cannabis Symposium in Denmark, Copenhagen. MJBizDaily’s European Cannabis Symposium will take place on Monday, May 6 at the Scandic Copenhagen Hotel in Copenhagen, Denmark. Leaders in the business, research and legislation of Europe’s medical marijuana and hemp market will gather for an intensive one-day conference offering educational sessions on the latest in tech, scientific research, and potential impacts on global markets. Table top exhibitors and an opening cocktail reception on Sunday, May 5 will also offer invaluable networking opportunities. “Regulated, normalized cannabis programs are just now starting to come into their own across Europe. As those government, industry and scientific ties continue to strengthen across the continent, the time is right to provide an in-person platform for e

LeddarTech Appoints Richard LaRue, a Seasoned Corporate International Lawyer, to its Executive Team23.4.2019 06:58:00 CESTPressemelding

LeddarTech Increases Automotive LiDAR Expertise with a Research and Development Team in Toronto, Canada LeddarTech enhances its senior management leadership team through the appointment of a Chief Legal Officer and further accelerates time to market by announcing the official opening of the Automotive Center of Excellence R&D facility in Toronto, Canada. QUEBEC CITY, April 23, 2019 (GLOBE NEWSWIRE) -- LeddarTech®, an industry leader providing the most versatile and scalable auto and mobility LiDAR platform ™, is pleased to announce the appointment of Mr. Richard LaRue as Chief Legal Officer. Mr. LaRue has worked extensively with software and biotech companies, as well as start-ups, in all aspects of their business, including their constitution, the negotiation, and drafting of international agreements and their equity and debt financing. He has practiced in these areas across Canada, Europe, and the U.S. “I look forward to leveraging my international experience in corporate law, financ

WillScot to Announce First Quarter 2019 Results on May 2, 201922.4.2019 22:04:00 CESTPressemelding

BALTIMORE, April 22, 2019 (GLOBE NEWSWIRE) -- WillScot Corporation (“WillScot”) (NASDAQ: WSC) today announced that it will release its first quarter 2019 financial results on Thursday, May 2, 2019 after the markets close. President and Chief Executive Officer, Bradley Soultz, and Chief Financial Officer, Timothy Boswell will host a conference call and webcast on Friday, May 3, 2019 at 10:00 a.m. EDT to discuss the results. The live call can be accessed by dialing (855) 312-9420 (US/Canada toll-free) or (210) 874-7774 (International). A live webcast will also be accessible via the “Events & Presentations” section of the Company’s Investor Relations website https://investors.willscot.com. An archived version of the webcast will be available for 60 days following the call. About WillScot Corporation Headquartered in Baltimore, Maryland, WillScot Corporation is the public holding company for the Williams Scotsman family of companies in the United States, Canada and Mexico. WillScot Corpora

SIMEX (OTC: ARGB), an infrastructure software platform22.4.2019 14:00:00 CESTPressemelding

LAS VEGAS, April 22, 2019 (GLOBE NEWSWIRE) -- President of SIMEX Inc., Vassili Oxenuk says: "Today, we can see the number of platforms called crypto exchanges has exceeded any reasonable number. Thus, investors wishing to participate in the development of the growing and promising crypto industry, it is difficult to understand the competitive advantages of such platforms. It is especially strange to see how investors contribute in projects that promise to do what has already been implemented in other companies and even works. We have created a product that meets all needs of the crypto market and any licensed company can simply take advantage using our software for a particular activity". SIMEX Inc, the corporation that has created a multifunctional platform implementing functions listed below and currently existing company could perform as an investment bank and crypto exchange, looking to enter markets and cover as many jurisdictions as possible. In that aspect, SIMEX STO tokens sale

Real World Cloud Orchestration Facilitates Easy Migration to All-IP18.4.2019 22:05:00 CESTPressemelding

For All-IP service providers in Malta and the Netherlands, Patton Cloud edge orchestration has lowered costs with fast, simple activation and management of enterprise IP-Telephony services SmartNode VoIP… More than Just Talk! BERN, Switzerland, April 18, 2019 (GLOBE NEWSWIRE) -- Patton—a U.S. network-equipment manufacturer and multi-national provider of enabling solutions for virtualized network function virtualization (NFV) SD-WAN, All-IP, and unified communications (UC) services—has saved the day for Dutch and Maltese national IP-communications providers with its Patton Cloud network edge orchestration service. VIDEO: Cloud Powered Services Netherlands ISDN Services are going away in the Netherlands. Yet scores of business subscribers can't simply jump into an All-IP network overnight. Investments in ISDN-based systems, fused with established business-processes, preclude such reckless dismantling of on-premise legacy systems. Business customers need flexibility to manage migration to