Octapharma to Sponsor Two Symposia at the 2016 World Federation of Hemophilia (WFH) World Congress in Orlando, USA
Octapharma will sponsor a range of activities at this year’s WFH World Congress in Orlando, USA, including two symposia and a number of posters and scientific presentations highlighting Octapharma’s recent developments in haemophilia A and von Willebrand disease (VWD).
The first symposium, “Simple solutions to complex issues: Addressing today’s challenges in VWD and haemophilia A” on Monday 25 July 2016, will be chaired by Professor Erik Berntorp (Lund University, Malmö, Sweden) and will explore current clinical issues in the management of patients with VWD and haemophilia A. New insights into prophylactic therapy for VWD patients will be discussed, including the management of bleeding in patients in the perioperative setting, and special issues related to VWD in women will be addressed. The latest clinical experiences with wilate®, a high purity, double virus-inactivated VWF/FVIII concentrate containing both factors in a physiological 1:1 ratio, will be presented including its use in immune tolerance induction in haemophilia A patients with FVIII inhibitors.
Major challenges in current haemophilia A treatment include the development of inhibitors and the need for frequent venous access for FVIII injection. Octapharma’s human cell line recombinant FVIII Nuwiq® (Human-cl rhFVIII)®, is a fourth generation rFVIII derived from a human cell line without chemical modification or fusion with any other protein and is devoid of antigenic non-human epitopes1,2. The development aim of Nuwiq® is to address the challenges of FVIII inhibitors and frequent infusions required during prophylaxis.
The second symposium, “A focus on human cell-line derived rFVIII in haemophilia A: Update on clinical experience with Nuwiq® in PUPs and PTPs” on Wednesday 27 July, will be chaired by Professor Craig Kessler (Georgetown University Medical Centre, Washington DC, USA) and will provide an opportunity to discuss the current complex issues in haemophilia A and the latest experience with Nuwiq®. The risk of inhibitor development throughout the life of haemophilia A patients, taking into account factors such as age and the need for intensive treatment during surgery will be reviewed. New interim data from a clinical study of Nuwiq® in previously untreated patients (PUPs) will be presented, as well as the importance of PK-guided personalised prophylaxis and its potential to reduce the number of infusions and bleeding rates.
In addition, the following scientific posters will be presented during the congress:
- Individualized prophylaxis with Nuwiq® (Human-cl rhFVIII) in previously treated adults with severe haemophilia A who had received regular routine prophylaxis in the past
- PUPs with Severe Haemophilia A - A GCP Study Evaluating the Immunogenicity, Efficacy and Safety of Nuwiq® (NuProtect)
- Individual baseline thrombin generation and bleeding rate during personalized prophylaxis with Nuwiq® in previously treated patients with severe haemophilia A
- Long-term Immunogenicity, Safety and Efficacy of Human-cl rhFVIII in Previously Treated Children with Severe Haemophilia A
- Experience with Nuwiq® in clinical trials with previously treated paediatric and adult patients
- Surveillance Study of Safety and Efficacy of a VWF/FVIII concentrate in patients with von Willebrand disease (VWD) – data report from an ongoing study (Wil-20)
- Immune tolerance induction in haemophilia A inhibitor patients with a single factor VIII/von Willebrand factor concentrate in an observational immune tolerance induction study (ObsITI)
- Disease severity as a predictor of response to immune tolerance induction (ITI) in adult patients with haemophilia A and high titer inhibitors
- Pharmacokinetic (PK) Comparison of Two Fibrinogen Concentrates in Patients with Congenital Fibrinogen Deficiency: final analysis.
About von Willebrand Disease
VWD is the most common of the inherited bleeding disorders, with approximately 1% of the population having VWF levels below normal. VWD is classified as type 1 (generally mild), type 2 (variable) or type 3 (severe). The symptoms of VWD are usually those of platelet dysfunction and include nose bleeds, skin bruises and haematomas, prolonged bleeds from trivial wounds, oral cavity bleeding, and excessive menstrual bleeding. Gastrointestinal bleeds are relatively rare, but may be very serious when they occur. Severe deficiency of VWF, or a specific defect in the interaction of VWF with FVIII, causes a secondary moderate deficiency of FVIII. These patients may have symptoms that are more characteristic of haemophilia, such as bleeds into joints or soft tissues including muscle and brain.
About Haemophilia A
Haemophilia A is an X-linked hereditary disorder caused by FVIII deficiency which if left untreated leads to haemorrhages in muscles and joints and consequently to arthropathy and severe morbidity. FVIII replacement prophylactic treatment reduces the number of bleeding episodes and the risk of permanent joint damage. This disorder affects one in every 5,000 to 10,000 men worldwide. Globally, 75% of haemophilia cases are left undiagnosed or untreated. The development of neutralising FVIII antibodies (FVIII inhibitors) against infused FVIII represents the most serious treatment complication. The cumulative risk of FVIII inhibitor development is reported to be currently up to 38%.
Headquartered in Lachen, Switzerland, Octapharma is one of the largest human protein manufacturers in the world, developing and producing human proteins from human plasma and human cell lines.
As a family-owned company, Octapharma believes in investing to make a difference in people’s lives and has been doing so since 1983; because it’s in our blood.
Octapharma employs approximately 6,400 people worldwide to support the treatment of patients in 105 countries with products across three therapeutic areas:
• Critical Care
• Haematology (coagulation disorders)
• Immunotherapy (immune disorders)
Octapharma owns five state-of-the-art production facilities in Austria, France, Germany, Mexico and Sweden.
For more information visit www.octapharma.com
1. FDA Memorandum to Octapharma dated 09 October 2014, reference STN 125555\0
2. Kannicht et al. Thrombosis Research 2013; 131: 78–88
Om Business Wire
Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.
Følg saker fra Business Wire
Registrer deg med din epostadresse under for å få de nyeste sakene fra Business Wire på epost fortløpende. Du kan melde deg av når som helst.
Siste saker fra Business Wire
AstraZeneca and Chi-Med’s Savolitinib Shows Encouraging Clinical Activity in 2nd-Line EGFR Mutation-positive Lung Cancer with MET-amplification16.10.2017 22:00 | Pressemelding
AstraZeneca and its partner Chi-Med today presented preliminary safety and clinical activity of savolitinib when given in combination with either Tagrisso (osimertinib) or Iressa (gefitinib) in two Phase Ib trials conducted in patients with epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC) with MET-amplification who had progressed following 1st-line treatment with an EGFR inhibitor.1,2 In both trials, the addition of savolitinib (600mg, once daily), an investigational selective inhibitor of c-MET (mesenchymal epithelial transition factor) receptor tyrosine kinase, to osimertinib (80mg, once daily) or gefitinib (250mg, once daily) demonstrated preliminary anti-tumour activity. The data were shared in two oral presentations at the International Association for the Study of Lung Cancer 18th World Conference on Lung Cancer (WCLC) in Yokohama, Japan, 15-18 Oc
Orlando Melbourne Int’l (MLB) Lands Largest FAA Grant in Its History16.10.2017 21:34 | Pressemelding
When Air Force One landed at Orlando Melbourne International Airport (MLB) in February, Airport Executive Director Greg Donovan took advantage of the opportunity and advised the president of the United States that his 747-200 just landed on a commercial runway officially rated ‘poor’ in aviation terms. That’s going to change, thanks to an $18,132,588 FAA grant announced by U.S. Secretary of Transportation Elaine Chao today. This press release features multimedia. View the full release here: http://www.businesswire.com/news/home/20171016006292/en/ Greg Donovan, A.A.E. (Photo: Business Wire) “We asked for, and received, tremendous support from the Florida congressional delegation,” said Jack L. Ryals, chairman of the Melbourne Airport Authority. “We are deeply grateful to Congressman Posey, Senator Nelson and Senator Rubio for their advocacy on this critic
Colombia Selects IDEMIA to Upgrade Its Identification and Civil Registry Platform16.10.2017 14:34 | Pressemelding
IDEMIA, the global leader in trusted identities for an increasingly digital world, has been selected by the National Civil Registry of Colombia (Registraduría Nacional del Estado Civil de Colombia – RNEC 1 ) to update the identification and civil registry platform. This platform is the trusted repository of citizens’ biometric and alphanumeric data and ensures the uniqueness of identities. IDEMIA (formerly known as OT-Morpho) has worked with the RNEC since the beginning of this project and has constantly supported the successive improvements of the solution. In 2017, when in need to strengthen the platform in order to offer new services to the government and to the population while maintaining a high level of security and satisfaction of the users, RNEC decided to pursue its partnership with IDEMIA. Through this new contract, IDEMIA will e
ATB Financial Goes-Live on Murex’s SaaS Solution16.10.2017 14:00 | Pressemelding
Sibos - Murex, a global leader in trading, risk management and processing solutions, is pleased to announce the successful launch of the MX.3 SaaS solution at ATB Financial. MUREX SaaS is a managed services offering for the MX.3 platform, encompassing infrastructure and application management. This press release features multimedia. View the full release here: http://www.businesswire.com/news/home/20171016005092/en/ ATB pursued this initiative in order to create a simple yet comprehensive foreign exchange experience for their customers. In addition to the customer benefit, ATB was also able to rationalize their IT landscape, broaden the scope of financial instruments they provide on their digital platform, and prepare for a large volume increase in their trading activities. Due to the strength of the solution’s risk management capabilities, extensive asset class coverage, and the ra
Leave a review on print24.com and win a VW up!16.10.2017 13:59 | Pressemelding
The online print shop UNITEDPRINT SE, owner of renowned brands including print24.com, is asking its customers for their opinions on the company’s products and services. In return for their views, customers will receive vouchers and be entered into a prize draw. The online print shop is offering one voucher for every review submitted across various portals. The vouchers – worth up to €25.00 and valid until 31 March 2018 – will be subject to a minimum order amount (product price inc. VAT, not including delivery) of €250.00 per voucher. All reviews received up to 31 December 2017 will be eligible, regardless of length and content. You can learn more about the review campaign at https://print24.com/rate/ But not only that, print24.com is also giving every reviewer the chance to win a brand-new VW up! Ali Jason Bazooband, Managing Director for Innovation/Marketing at print24.com,
Bentley Systems Announces Winners of 2017 Be Inspired Awards16.10.2017 13:52 | Pressemelding
The Year in Infrastructure 2017 Conference – Bentley Systems, Incorporated, a leading global provider of comprehensive software solutions for advancing infrastructure, has announced the winners of the 2017 Be Inspired Awards. The annual awards program honors the extraordinary work of Bentley users advancing the world’s infrastructure. At a ceremony and gala at their Year in Infrastructure 2017 Conference, Bentley acknowledged 17 Be Inspired Awards winners and six Special Recognition Awards winners. The Year in Infrastructure Conference is Bentley’s annual global gathering of leading professionals in the world of infrastructure design, construction, and operations. In addition to thought-provoking keynotes, technology demonstrations, industry forums, and panel discussions, the agenda included presentations by finalists in the Be Inspired Awards program, culminating in the selection of t
I vårt presserom finner du alle våre siste saker, kontaktpersoner, bilder, dokumenter og annen relevant informasjon om oss.Besøk vårt presserom