Business Wire

Morinaga Milk's New Probiotic Strain, Bifidobacterium breve A1, May Prevent Onset of Alzheimer's Disease

Del

Morinaga Milk Industry Co., Ltd. (TOKYO:2264), a leading Japanese dairy product company, today announced the results of a new study investigating the preventive effects of its new probiotic strain Bifidobacterium breve A1 on a model of Alzheimer’s disease. Researchers found that B. breve A1 improved spatial recognition capability, as well as learning and memory capabilities, in cognitively deficient mice, indicating it could play an important role in preventing the onset of Alzheimer’s Disease in humans.1

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20180320005052/en/

(Fig. 1) Effects of B. Breve A1 in improving spatial recognition, learning and memory capabilities   ...

(Fig. 1) Effects of B. Breve A1 in improving spatial recognition, learning and memory capabilities (Graphic: Business Wire)

The number of patients affected by dementia is increasing worldwide. One report estimates there were 46.8 million people worldwide living with dementia in 2015 and projects this number will reach 131.5 million by 2050.2 Alzheimer’s disease accounts for a large proportion of dementia cases. Like many chronic diseases, Alzheimer’s develops slowly for several decades before the onset of symptoms, even though deterioration in the brain begins in the early stages. Once the disease has developed, it is difficult to reverse it or even halt its progression; therefore, finding effective countermeasures to prevent the disease’s onset is a top priority for researchers.

The “gut‒brain axis,” which is the functional linkage between the brain and gut microbiota, has attracted attention worldwide. Because probiotics are known to have beneficial effects on gut microbiota, they are a promising treatment for brain health. Indeed, both bifidobacteria and lactobacillus have shown beneficial effects on anxiety and depression.

Building on this research, Morinaga Milk investigated the ability of probiotics to prevent the progression of Alzheimer’s disease in collaboration with Professor Keiko Abe from The University of Tokyo and Kanagawa Institute of Industrial Science and Technology. The study, published in the journal Scientific Reports, revealed the potential of B. breve A1 to prevent the onset of Alzheimer’s disease.

Study Method

Mice were injected with amyloid β — the substance presumed to cause Alzheimer’s disease — in order to induce cognitive dysfunction in a model of Alzheimer’s disease. Mice in the active treatment group were administered B. breve A1 (1 × 109 per day) orally for 10 days (B. breve A1 group). Mice in the control group were given either saline (saline group) or a cholinesterase inhibitor, a medication prescribed for dementia (positive control group). Cognitive function was evaluated by a Y maze test and a passive avoidance test.

Y maze Behavioral Test Confirms Improvement of Spatial Recognition Capability

“Spontaneous alternation” refers to the tendency of normal mice to choose a different path when navigating a maze than the last one chosen, indicating they remember what paths they have already tried. In this study, amyloid β injected mice given saline showed a remarkable reduction in spontaneous alternation rate in the Y maze test compared to normal mice. However, the B. breve A1 group showed a significant improvement in spontaneous alternation rate compared to the saline group. These results indicate that B. breve A1 improves spatial recognition capability (Fig. 1, left).

Passive Avoidance Behavioral Test Reveals Improvement in Learning and Memory Capability

During the passive avoidance test, mice need to learn to avoid a negative stimulus by staying away from a certain area. If they do so successfully, it indicates they remember the negative experience. Similar to the Y maze behavioral test, mice in the B. breve A1 group stayed longer in the area without a negative stimulus compared to the saline group. This result indicates that B. breve A1 improves learning and memory capabilities (Fig. 1, right).

B. breve A1 Nearly as Effective as Common Alzheimer’s Drug

The improvements in both the Y maze test and the passive avoidance test were similar in magnitude to those observed in the positive control group treated with a cholinesterase inhibitor, a medication commonly prescribed for Alzheimer’s disease, indicating that B. breve A1 has similar potential to improve amyloid-induced cognitive impairment.

Hippocampus Gene Expression is Key Behind Mechanism of Action

Morinaga Milk focused on the hippocampus, the area of the brain associated with memory and learning capabilities, by performing comprehensive gene expression analysis in the hippocampus of the mice. The researchers found the expression of many genes was altered; particularly, gene groups associated with immunological reactions and inflammation were changed, causing immunological abnormalities and excessive inflammation in the impaired mice ingesting saline. In contrast, the expression of the majority of these genes remained normal in impaired mice ingesting B. breve A1 (Fig. 2).

These findings led Dr. Jin-zhong Xiao, General Manager of Morinaga Milk’s Next Generation Science Institute, to state that “Intake of B. breve A1 suppressed excessive immunological reactions and inflammation in the brains of the mice and improved cognitive function.” He went on to add, “Chronic inflammation of the brain is characteristic of Alzheimer’s disease. B. breve A1’s ability to suppress inflammation in the hippocampus is the key behind its ability to prevent progression of the disease.” The company plans to continue to research the effects of B. breve A1 on human subjects to further explore its therapeutic potential for preventing Alzheimer’s disease onset.

About Morinaga Milk

Morinaga Milk Industry Co., Ltd. is one of the leading dairy product companies in Japan. Morinaga Milk started research on bifidobacteria in the 1960s, inspired by the fact that bifidobacteria are the predominant bacteria residing in the intestines of breast-fed infants. In 1969, Morinaga Milk isolated its flagship strain Bifidobacterium longum BB536 from an infant. Morinaga Milk excels in innovative technology and offers various dairy products and other beneficial functional ingredients to customers around the world.

 

Reference

1.   Y. Kobayashi et al. Therapeutic potential of Bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer’s disease. Scientific Reports 7(1). Dec. 2017.
2.

World Alzheimer Report 2016

Contact information

Morinaga Milk Industry Co., Ltd.
Mai Nozawa, +81-3-3798-0152
m-nozawa@morinagamilk.co.jp
http://www.morinagamilk.co.jp/english/

Om Business Wire

Business Wire
Business Wire
24 Martin Lane
EC4R 0DR London

+44 20 7626 1982http://www.businesswire.co.uk

(c) 2018 Business Wire, Inc., All rights reserved.

Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.

Følg saker fra Business Wire

Registrer deg med din epostadresse under for å få de nyeste sakene fra Business Wire på epost fortløpende. Du kan melde deg av når som helst.

Siste saker fra Business Wire

Huawei Rewrites the Rules of Photography with Groundbreaking HUAWEI P30 Series26.3.2019 16:04:00 CETPressemelding

During an exclusive launch event today at the Paris Convention Center, Huawei Consumer Business Group (BG) unveiled the HUAWEI P30 and HUAWEI P30 Pro. The HUAWEI P30 Series builds on the HUAWEI P Series DNA in design and photography and is the company’s most advanced series of smartphone cameras. These devices feature the innovative HUAWEI SuperSpectrum Sensor, an optical SuperZoom Lens, a new HUAWEI Time of Flight (ToF) Camera, and enhanced optical and AI image stabilization technology. With these revolutionary technologies, the HUAWEI P30 and HUAWEI P30 Pro capture incredible photos and videos in every scenario. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20190326005752/en/ HUAWEI P30 Series (Photo: Business Wire) Richard Yu, CEO of Huawei Consumer BG, said, “the HUAWEI P30 Series is a fundamental breakthrough after decades of digital camera technology development; it will rewrite the rules and reshape everyone’s percepti

Takeda Presents New Data at the Endocrine Society’s 2019 Annual Meeting about the Patient Burden and Long-Term Impact of Chronic Hypoparathyroidism26.3.2019 15:01:00 CETPressemelding

Takeda Pharmaceutical Company Limited (TSE:4502/NYSE:TAK) (“Takeda”) this week shared new data revealing the burden of chronic hypoparathyroidism on patients and caregivers, as well as potential long-term risks of renal and cardiovascular complications that patients treated with conventional therapy may experience. Six-year results from the open-label long-term safety and efficacy RACE study were also announced. Data was presented at the Endocrine Society’s 2019 Annual Meeting (ENDO) from 23–26 March in New Orleans, Louisiana, USA. “Results from the Burden of Illness Global Survey in 13 countries reveal the extent of the impact hypoparathyroidism has on patients and their caregivers throughout their daily lives,” said John Bilezikian M.D., Professor of Medicine at the Columbia University Irving Medical Center, New York, NY, USA. “This offers important insights and enables us to take a more holistic approach in the management of these patients due to a greater understanding of the poten

LEO Pharma Standardizes on Veeva Development Cloud to Speed Drug Development26.3.2019 14:58:00 CETPressemelding

Veeva Systems (NYSE:VEEV) today announced that LEO Pharma, a global leader in medical dermatology, selected Veeva Development Cloud applications to help drive end-to-end business processes across product development. The company will utilize the Vault Clinical, Vault RIM, and Vault Quality suites to unify drug development on a single cloud platform. With Veeva Development Cloud, LEO Pharma can bring together applications for clinical, regulatory, and quality for even greater efficiency and compliance throughout the product development lifecycle. “LEO Pharma R&D has embarked on an ambitious strategy for 2025, which will pave the way for our ambitions to continuously pioneer dermatology. This requires that we are able to drive science globally, whilst at the same time securing timely delivery on our pipeline,” said Kim Kjøller, executive vice president of global research and development at LEO Pharma. “Veeva Development Cloud gives us a unified platform that can enable us to maximize eff

Keio Plaza Hotel Tokyo Hosts Japanese Sword Culture, Armor Exhibition – “Japan’s Soul and Beauty of Swords and Armor by Legendary Artisans”26.3.2019 14:05:00 CETPressemelding

Keio Plaza Hotel Tokyo (KPH), one of Japan’s most prestigious international hotels located in Shinjuku, Tokyo, will host a special exhibition entitled “Japan’s Soul and Beauty of Swords and Armor by Legendary Artisans” displaying beautiful Japanese swords and armor from April 25 (Thursday) to June 27 (Thursday), 2019 in the 3rd floor lobby of our Hotel. This exhibition is part of our series of cultural programs designed to introduce various aspects of Japanese culture to our guests visiting the Hotel from over 100 different countries around the world. Various precious and old swords and armor made during the Heian Period (794-1185) and other periods of Japanese history will be displayed, along with “tsuba” (Sword handle guards separating the handle from the blade) and other ornate sword fittings. On May 14, two masters of sword-drawing from Ryushin Shouchi School will give a live performance in the Main lobby from 5:00 p.m. This press release features multimedia. View the full release

Andersen Global Enters Qatar26.3.2019 13:30:00 CETPressemelding

Andersen Global today announced a collaborating agreement in Qatar with Al-Khalifa Law, a leading Doha-based law firm. The collaboration is Andersen Global’s first in Qatar and is part of the organization’s continued growth in the Middle East. Al-Khalifa Law was founded 20 years ago and established itself as a premier firm in the region. The team at Al-Khalifa Law has diversified, deep experience providing services in a wide variety of business sectors, such as commercial contracts, taxation, employment, real estate and retail, intellectual property, dispute resolution and litigation and arbitration. “A collaboration with Andersen Global, which brings with it a culture of stewardship, transparency, and providing best-in-class services, was an obvious decision for us,” said Hamzeh Abdelhady, Office Managing Director of Al-Khalifa Law. “We will be able to continue providing quality services in the market and bring a premier, seamless association of experts throughout the world directly t

Vivior’s System Cleared for CE Mark – Market Introduction This Year in Europe26.3.2019 13:18:00 CETPressemelding

Vivior has cleared their system as a Class I medical device and is planning the market introduction later this year in Switzerland and the European Union. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20190326005594/en/ The Visual Behavior Monitor (Photo: Business Wire) Vivior has notified Swissmedic about their product, the Visual Behavior Monitor, and fulfills all requirements for a medical device Class I according to the Medical Device Directive (MDD). With this important step, Vivior is now allowed to sell their system in Switzerland and the European Union. Mario Stark, CEO at Vivior, explains: “We are happy to be able to start market introduction and will, in a first step, work with selected clinics in Europe.” Prof. Michael Mrochen, Chairman of the Board of Directors, adds: “This constitutes an important milestone in the development of the Vivior system. We are now ready to support eye care professionals in offering the