Business Wire

Led by Oncology Sector, Life Sciences Deal Market Value Increases in 2017 Despite Downward Trend in Deal Volume

Del

Clarivate Analytics, the global leader in providing trusted insights and analytics to accelerate the pace of innovation, has revealed that the market value of the most innovative and impactful global life sciences transactions of 2017 increased by 6% totaling US $364 billion, despite a decrease in overall deal volume. The transactions nominated for the annual Clarivate Cortellis Deal of the Year Awards include licensing and mergers and acquisitions. The announcement of the nominees at the 36th Annual J.P. Morgan Healthcare Conference in San Francisco coincided with the Clarivate Deals and Portfolio Annual Review presentation – the foremost independent analysis of the economic trends shaping the life sciences sector in 2017.

Clarivate’s Deals and Portfolio Annual Review showcased a deep-dive analysis of 4,234 life sciences transactions. While overall the aggregate dollar value for deals increased from 2016, deal volume dropped by approximately 3% and saw contractions in almost every type of deal structure. This represents a reversal from last year when deal volume was up, but deal dollars were down.

“There is a healthy appetite for acquisitions and strong liquidity for deals in today’s market, but several factors contributed to deal volume falling below the last two years,” said Laura Vitez, commercial insights manager at Clarivate. “2017 saw a stronger IPO market for biopharma than the previous year, which meant companies had more viable alternatives to stay independent. We also experienced high valuations that resulted in heightened expectations during deal discussions. Finally, we saw many U.S. companies take a wait-and-see approach as the prospects for corporate tax reform played out right up to the end of the year.”

A total of ten Deal of the Year nominees was announced, five each in the categories of M&A and licensing. They include some of the industry’s most recognizable names (AstraZeneca, Celgene, and Merck) and life sciences upstarts like Rigontec, CureVac, and IFM Therapeutics. Nominees were recognized for innovations in creative deal structures, the use of novel technology, addressing unmet medical needs and new market penetrations. The analysis was drawn from the Cortellis suite of solutions from Clarivate Analytics. Industry participants may vote for the Deals of the Year at http://info.clarivate.com/DOTY. Winners will be announced in the beginning of February 2018.

Vitez added: “2018 shows promise for significant deal making, driven in large part by the lower corporate tax rates and tax repatriation allowances that were included in the final U.S. tax bill signed in December. U.S. biopharma companies comprise one-third of the top U.S. companies’ offshore cash holdings. When combined with the new lower corporate tax rates, we anticipate a considerable amount of the tax savings and repatriated cash will be used for M&A activities.”

This year’s Deals and Portfolio Review included a particularly deep investigation into oncology trends, which account for the largest number of M&A transactions by therapeutic area and the largest volume of licensing transactions. All but one of the top 20 dealmakers were active in oncology transactions last year.

“Oncology deals represented more than three times as many deals as neuroscience, the next most prevalent therapeutic area,” said Jaime Munro, global practice leader for portfolio and licensing at Clarivate. “Interestingly, we are seeing a trend of oncology deals focusing on earlier stages, with discovery and preclinical assets the focus of nearly two-thirds of oncology deals.”

2017 Deal of the Year nominees are:

M&A

J&J/Actelion
Johnson & Johnson agreed to acquire Actelion in a $30 billion deal that is second in size only to the 2009 Roche/Genentech merger in pharma and biotech M&A. J&J gains the worldwide rights to ponesimod and cadazolid, while Actelion spins out its research and early-stage assets into a new company.

Bioverativ/True North
Bioverativ acquired True North, a private, clinical stage company focused on candidates for complement-mediated diseases, for $825 million total with $400 million upfront. This early acquisition, which included $425 million in milestones, strengthens innovation in a rare blood disease.

BMS/IFM Therapeutics
In a deal that had everything – a young firm, cool technology and a spinout – BMS acquired IFM for $2.32 billion, with $300 million upfront. The cancer sector deal includes $1.01 billion in milestones for IFM’s preclinical STING (simulator of interferon genes) and NLRP3 agonist programs.

Gilead/Kite
Gilead acquired Kite, a developer of cell therapies for cancer treatment that express either a chimeric antigen receptor (CAR) or an engineered T-cell receptor (TCR), depending on the cancer type. This transformative $11.9 billion deal brings immuno-oncology to the forefront at Gilead.

Merck/Rigontec
Merck acquired Rigontec, a University of Bonn spinout focused on developing retinotic acid-inducible gene 1 (RIG-1) targeting therapies for various tumors. The $552.3 million acquisition was a smartly structured early sale, and RIG-1 has potential with Merck’s Keytruda.

Licensing

AstraZeneca/Pieris
The companies entered into a $2.145 billion deal that included $45 million upfront, under which AstraZeneca would develop and commercialize inhaled respiratory drugs, including PRS-060, using Pieris's Anticalin platform for respiratory diseases. The transaction leverages a novel technological modality with multiple co-development opt-ins.

Celgene/BeiGene
Celgene and BeiGene entered into a licensing agreement to develop and commercialize cancer drug BGB-A317 to combat solid tumors. The $1.292 billion deal includes $263 million in upfront cash and a $150 million equity stake. The deal is a win for both companies, as Celgene gets a PD-1 for its immuno-oncology backbone, while BeiGene gains an instant China portfolio.

Amgen/CytomyX
This creatively structured $1.668 billion discovery stage licensing deal includes $40 million in upfront cash and $20 million in equity for the development of T-cell engaging bispecific antibodies against EGFR and certain immuno-oncology targets worldwide.

Eli Lilly/CureVac
Eli Lilly licensed CureVac’s RNActive technology for the development and commercialization of up to five cancer vaccine products worldwide. A $1.803 billion deal with $50 million upfront and a $53 million equity stake, this is CureVac's largest collaboration to date, highlighting the industry's move toward targeting neoantigens.

AbbVie/Alector
Under this discovery stage deal, AbbVie will develop and commercialize Alector's immune therapies against Alzheimer’s disease and other neurodegenerative disorders worldwide. It works toward the promise of immuno-neurology by targeting microglia and macrophages – immune cells in the brain. The $225 million announcement includes $205 million upfront and $20 million in equity.

About Clarivate Analytics
Clarivate™ Analytics is the global leader in providing trusted insights and analytics to accelerate the pace of innovation. Building on a heritage going back more than a century and a half, we have built some of the most trusted brands across the innovation lifecycle, including the Web of Science™, Cortellis™, Derwent™, CompuMark™, MarkMonitor® and Techstreet™. Today, Clarivate Analytics is a new and independent company on a bold entrepreneurial mission, to help our clients radically reduce the time from new ideas to life-changing innovations. For more information, please visit clarivate.com.

Contact information

Clarivate Analytics
Jason Milch, 312-379-9406
jmilch@baretzbrunelle.com

Om Business Wire

Business Wire
Business Wire
24 Martin Lane
EC4R 0DR London

+44 20 7626 1982http://www.businesswire.co.uk

(c) 2018 Business Wire, Inc., All rights reserved.

Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.

Følg saker fra Business Wire

Registrer deg med din epostadresse under for å få de nyeste sakene fra Business Wire på epost fortløpende. Du kan melde deg av når som helst.

Siste saker fra Business Wire

CHMP Grants Positive Opinion for New Indication of Clovis Oncology’s Rubraca®▼ (rucaparib) Tablets as Maintenance Treatment for Women with Relapsed Ovarian Cancer13.12.2018 17:46Pressemelding

Clovis Oncology, Inc. (NASDAQ: CLVS) today announced that the European Union’s (EU) European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion recommending an additional indication to include rucaparib as monotherapy for the maintenance treatment of adult patients with platinum-sensitive relapsed high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in response (complete or partial) to platinum-based chemotherapy. EC approval is anticipated in the first quarter of 2019. Once approved, Rubraca’s indication will expand beyond its initial Marketing Authorization in Europe granted in May 2018 for adult patients with platinum-sensitive, relapsed or progressive, BRCA mutated (germline and/or somatic), high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer, who have been treated with two or more prior lines of platinum-based chemotherapy, and who are unable to tolerate further platinum

Dole Food Company Sells Fresh Cut Business in Sweden and Finland13.12.2018 17:00Pressemelding

Dole Food Company, Inc., announced today an agreement to sell Saba Fresh Cuts AB and Saba Fresh Cuts OY to BAMA International. Saba Fresh Cuts AB—with production facility in Helsingborg Sweden—and Saba Fresh Cuts OY—with production facility in Espoo Finland—are producers of washed and ready-to-eat salads. The companies prepare and sell various fresh-cut salads and vegetables to the retail and foodservice industry in Sweden, Denmark, Finland, Germany and the Baltic States. The sale of Saba Fresh Cuts AB was a necessary condition of the European Commission’s approval of the investment by Total Produce into Dole in July 2018. “I am very pleased with the outcome of this sale in meeting the EU’s requirement,” said Mr. Johan Linden, President and Chief Executive Officer of Dole Food Company, “and I am confident that Saba Fresh Cuts will be in good hands under BAMA’s ownership.” "We are pleased to announce this agreement with Dole for Saba Fresh Cuts. Convenience products and ready-to-eat sal

Thales and Gemalto Are Granted Regulatory Clearance by the Commerce Commission in New Zealand13.12.2018 16:00Pressemelding

Regulatory News: Reference is made to the joint press release by Thales (Euronext Paris: HO) and Gemalto (Euronext Amsterdam and Paris: GTO) dated 27 March 2018 in relation to the launch of the recommended all-cash offer by Thales for all the issued and outstanding shares of Gemalto (the “Offer”), the publication of the Offer Document, and the joint press release of Thales and Gemalto dated 10 August 2018 in relation to the further extension of the Acceptance Period. Terms not defined in this press release will have the meaning as set forth in the Offer Document. Thales and Gemalto announce today that they have received merger control Regulatory Clearance from the Commerce Commission in New Zealand, following Thales’s commitment to divest its general purpose hardware security modules (GP HSM) business globally1 to a suitable purchaser. This clearance is effective immediately. Together with the antitrust clearances obtained in China, Israel, South Africa, Turkey, and for the European Un

Hurricane Electric Becomes First Internet Backbone to Connect to 200 Internet Exchanges around the Globe13.12.2018 15:37Pressemelding

Hurricane Electric, the world’s largest IPv6-native Internet backbone, today announced that it is the first Internet backbone in the world to connect to over 200 unique Internet exchanges. As an early leader in the switch to IPv6, Hurricane Electric now connects to the largest number of networks on the planet for both IPv6 and IPv4 and has been at the forefront of providing high-speed Internet connectivity to organizations throughout the world using:100GE (100 Gigabit Ethernet), 10GE (10 Gigabit Ethernet), and GigE (1 Gigabit Ethernet) connections. As a result of the improved connectivity with these 200 exchanges, customers receive the benefit of lower latency, higher throughput and increased fault tolerance. This reliable connectivity is especially important as global IP traffic continues to increase – Cisco’s Visual Networking Index: Forecast and Trends, 2017–2022 predicts that annual global IP traffic will reach 4.8 zettabytes (ZB) per year by 2022, or 396 exabytes (EB) per month, t

The World's Largest Heritage and Culture Festival to Begin With the Slogan Janadria 33 Faithfulness and Loyalty13.12.2018 15:15Pressemelding

With the support and under the patronage of the Custodian of the Two Holy Mosques King Salman bin Abdulaziz, the 33rd Edition of the National Festival of Heritage and Culture will be held in Janadria for 21 days from Thursday 20th December 2018 to Wednesday 9th January 2019. Organized by the Saudi Ministry of National Guard, the festival is part of the efforts to intensify attention to Saudi heritage, expose it regionally and globally and to promote dialogue among cultures and civilizations on the level of people and nations. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20181213005472/en/ The Custodian of the Two Holy Mosques King Salman bin Abdulaziz (Photo: AETOSWire) Janadria is the largest Saudi cultural festival that simulates the history, present and future of Saudi Arabia and the largest event of its kind in the region. Since 1985, it has witnessed extensive Saudi participation, a growing Arab and Gulf presence and an

PPG to Invest in Automated Dispense Cell Manufacturing for Automotive Parts and Accessories13.12.2018 14:32Pressemelding

PPG (NYSE: PPG) today announced that it is increasing its investment in automated dispense cell manufacturing of paint and related coatings for the automotive parts and accessories decorative (APAD) space. Financial details are not being disclosed. Dispense cell technology enables PPG to dramatically accelerate production and approval of paint batches for vehicle original equipment manufacturers (OEMs) and component suppliers. The technology allows coatings components to be automatically drawn from storage vats in the correct proportions and mixed directly in their shipping containers, vastly simplifying and increasing the efficiency of the coatings manufacturing process. PPG recently launched an APAD dispense cell operation at its San Juan del Rio, Mexico, coatings facility and will begin production on an additional cell in 2019 in Sriperumbudur, India. These cells are in addition to PPG’s recent APAD investments in Germany and Russia and the dispense cells already online at the Compa