Business Wire

GNT Pharma's Ropesalazine Effective in Treating Dog Dementia

Del

GNT Pharma said Ropesalazine, a drug candidate for Alzheimer’s disease (AD), has shown an outstanding beneficial efficacy in a pilot clinical trial conducted for dogs with cognitive dysfunction syndrome (CDS) or dementia.

CDS is a progressive neurodegenerative disorder of senior dogs and characterized by altered interaction with family, disorientation, sleep/wake cycle changes, increased house soiling, and activity change. There is no cure for the disease.

Ropesalazine is a multi-target drug to prevent both inflammation and free radicals that contribute to nerve cell death, amyloid plaque production, and neurofibrillary tangle formation which are pathological hallmarks of AD.

Ropesalazine was found to attenuate nerve cell death and amyloid plaques as well as inflammation and oxidative stress in transgenic AD mice models. Ropesalazine reduced cognitive deficit in APP/PS1 AD mice at early, moderate, and late stages. The safety of Ropesalazine was proven in human as well as rats and dogs.

GNT Pharma scientists noticed that CDS is accompanied by nerve cell death, amyloid plaques, and neurofibrillary tangles similar to AD, and designed a pilot study to investigate if Ropesalazine would alleviate signs of CDS.

The study was conducted on six companion dogs aged 10 or older that revealed severe cognitive dysfunction scored according to canine cognitive dysfunction rating scale and canine dementia scale. Within 8 weeks following daily oral administration of Ropesalazine, all six dogs returned to the normal range of cognitive function and daily activity.

Dr. Jae Bong Moon, veterinarian and head of Irion Animal Hospital in Seoul who led the study, was excited with the result, saying “The companion dogs failed to recognize their owners before the treatment. It was so amazing to see the dogs that wagged their tails for their owners and cuddled up to them within 8 weeks of Ropesalazine treatment. Ropesalazine appeared to cure CDS.”

Encouraged with promising efficacy of Ropesalazine for CDS, GNT Pharma will move toward the next clinical study for approval of Ropesalazine as a drug for the treatment of CDS. The company assigned Professor Byeong-Teck Kang, director of Chungbuk National University Veterinary Medical Center, as a principal investigator. GNT Pharma plans to complete the clinical trial and launch Ropesalazine for the treatment of CDS in companion animals in 2019.

“We are impressed with such a huge beneficial effect of Ropesalazine for CDS even within 8 weeks of treatment,” GNT Pharma CEO & President Byoung Joo Gwag said, “we will initiate a pivotal phase II study of Ropesalazine for patients with AD next year, hoping to launch Ropesalazine as the first disease-modifying AD therapy within next five years.”

Contact information

GNT Pharma
Dr. Jin Hwan Lee
jhlee@gntpharma.com
Tel. +82-31-8005-9910 (EXT.217)
Fax. +82-31-8005-9916

Om Business Wire

Business Wire
Business Wire
24 Martin Lane
EC4R 0DR London

+44 20 7626 1982http://www.businesswire.co.uk

(c) 2018 Business Wire, Inc., All rights reserved.

Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.

Følg saker fra Business Wire

Registrer deg med din epostadresse under for å få de nyeste sakene fra Business Wire på epost fortløpende. Du kan melde deg av når som helst.

Siste saker fra Business Wire

American Airlines Announces Nonstop Philadelphia (PHL) to Orlando Melbourne (MLB)21.9.2018 22:13Pressemelding

Glorious beaches by day and theme park fireworks by night just got more convenient for Philadelphia travelers. American Airlines announced today that it will begin nonstop flights to Orlando Melbourne International Airport (MLB) starting February 16, 2019. The Central Florida airport is conveniently located in the heart of the tourism region and is the closest airport to NASA rocket launches, Port Canaveral’s cruises and what critics call “some of the most beautiful beaches Florida has to offer.” The flights will depart Saturdays from Philadelphia at 8:05 a.m., arriving in Florida at 10:48 a.m. The Embraer 175 jet arrival time syncs perfectly with cruise ship noon early boarding. Melbourne Airport Express offers nonstop shuttle service to the port, and all major rental car companies are onsite. The return flight to PHL departs at 11:24 a.m. and arrives in PHL at 1:55 p.m., with enough time to connect to some of American’s largest international destinations, including recently announced

Amy Palladino Joins BCW as Executive Vice President, Managing Director, Corporate Practice21.9.2018 17:43Pressemelding

BCW (Burson Cohn & Wolfe), a leading global communications agency, today announced that Amy Palladino has joined the agency as Executive Vice President, Managing Director in the agency’s U.S. Corporate Practice. Based in New York, Palladino will focus on senior client counsel and executive positioning for the agency’s largest corporate clients. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20180921005507/en/ Amy Palladino Joins BCW (Burson Cohn & Wolfe) “Amy is a talented and highly experienced communications executive with a track record of solving clients’ complex challenges and building business through smart, integrated communications approaches,” said Chris Foster, President, North America, BCW. “Her creativity and judgement will be enormously valuable to our current and prospective clients.” Palladino has more than 20 years of experience advising global clients across numerous industries, including technology, healthcar

Heidelberg Engineering Announces the CE-Marking of ANTERION21.9.2018 16:41Pressemelding

Heidelberg Engineering, the leader in diagnostic imaging known for the internationally-acclaimed SPECTRALIS ® retina and glaucoma platform, announces the CE-marking of ANTERION ® – an innovative platform designed to transform anterior segment diagnostics and workflow. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20180921005442/en/ The new Heidelberg Engineering ANTERION® provides the most important anterior segment examinations and measurements in one modular, upgradeable platform. (Graphic: Business Wire) The new ANTERION provides the most important anterior segment examinations and measurements in one modular, upgradeable platform. It is a single, workflow-efficient solution that brings together corneal topography and tomography, anterior segment metrics, axial length measurement and IOL calculation to transform the day-to-day routine of busy practices and clinics. Heidelberg Engineering has leveraged its core OCT technolo

Florian Winterstein Becomes New CEO of Jedox21.9.2018 15:46Pressemelding

The supervisory board of Jedox AG, a leading vendor of business intelligence and enterprise planning software, has appointed Florian Winterstein as Chief Executive Officer (CEO) effective October 2, 2018. This nomination will support Jedox’s international growth and a new development phase initiated by its latest fund raising in April 2018 with Iris Capital, eCAPITAL entrepreneurial Partners AG and Wecken & Cie. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20180921005416/en/ Florian Winterstein (Photo: Business Wire) With 25 years of experience in strategy consulting and leadership in software and service organizations, Winterstein brings to the company a valuable combination of expertise in cloud solutions, business development, and value creation for customers and partners. As former Chief Strategy Officer of BravoSolution, he positioned the software-as-a-service company as trendsetting digitalization partner, extending it

Takeda Receives Positive CHMP Opinion Recommending ALUNBRIG® (brigatinib) for the Treatment of ALK+ Non-Small Cell Lung Cancer in Patients Previously Treated with Crizotinib21.9.2018 13:30Pressemelding

Takeda Pharmaceutical Company Limited (TSE: 4502) today announced that the European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion, recommending the full approval of ALUNBRIG® (brigatinib) as a monotherapy for the treatment of adult patients with anaplastic lymphoma kinase-positive (ALK+) advanced non-small cell lung cancer (NSCLC) previously treated with crizotinib. ALUNBRIG is a tyrosine kinase inhibitor (TKI) designed to target and inhibit the ALK mutation in NSCLC. Approximately three to five percent of NSCLC patients globally have the ALK mutation. If the CHMP opinion is affirmed, and the European Commission approves ALUNBRIG, it will become the only ALK inhibitor available in the European Union as a one tablet per day dose that can be taken with or without food. The randomized, global Phase 2 ALTA trial was designed to investigate the efficacy and safety of ALUNBRIG in patients with locally advanced or metastatic ALK+

Asda Selects HCL Technologies to Help Drive IT Transformation21.9.2018 12:16Pressemelding

HCL Technologies (HCL), a leading global technology company, today announced that it has been selected to help drive IT transformation at the UK’s third-largest grocery retailer, Asda. The three-year application services contract will see HCL transform Asda’s IT Application Services with a new DevOps delivery model to drive data and analytics and support back-office applications through the full lifecycle of development, testing and support. HCL will also build a central data management platform to enable Asda to improve its insight and analytics capabilities. Asda operates more than 600 stores across the UK, employing over 135,000 people. Asda wanted to adopt a more agile approach towards application development and testing. This would allow the company to respond faster to business requirements and reduce time to market, while driving better user experience and satisfaction. HCL was selected due to its extensive expertise in successfully delivering similar large scale IT transformati