Gilead Announces Data From New Preclinical Study Evaluating an Investigational TLR7 Agonist in SIV-Infected Monkeys
Gilead Sciences, Inc. (NASDAQ:GILD) today announced results from a preclinical study conducted in collaboration with researchers at Beth Israel Deaconess Medical Center evaluating a proprietary investigational oral toll-like receptor 7 (TLR7) agonist, GS-9620, and a related molecular analogue, GS-986, as part of an HIV eradication strategy. Data from the study conducted in simian immunodeficiency virus (SIV)-infected virally suppressed rhesus macaques on antiretroviral therapy (ART) demonstrate that TLR7 agonist treatment induced transient plasma SIV RNA blips and reduced SIV DNA. In addition, TLR7 agonist treatment resulted in subsequent prolonged virus suppression in some of the macaques after stopping ART. These data were presented in an oral session (Session O-7) at the 2016 Conference on Retroviruses and Opportunistic Infections (CROI) in Boston.
“Our ultimate goal with TLR7 agonist therapy is to stimulate the body to drive latent HIV out of viral reservoirs in infected cells and to enhance virus-specific immune responses in HIV-infected individuals,” said James Whitney, PhD, Assistant Professor of Medicine, Harvard Medical School, and Principal Investigator in the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center in Boston. Dr. Whitney is also an Associate Member of The Ragon Institute of MGH, MIT and Harvard. “This study demonstrates the approach has promise, and that lower, longer-term TLR7 agonist dosing may be a potentially useful approach to inducing long-term HIV-remission.”
Earlier research presented at CROI 2015 showed that GS-986 treatment, in combination with ART, reduced SIV DNA levels by 30 to 90 percent in some tissues. This follow-up study was designed to assess whether GS-9620 produced results similar to GS-986, and whether lower doses of the compounds would induce transient plasma viremia and/or perturb SIV viral reservoirs. A lower dose was chosen with the intent to minimize induction of peripheral interferon-alpha (IFN-alpha), an anti-viral protein that can cause adverse events.
In this placebo-controlled study, SIV-infected rhesus macaques received ART beginning day 65 post-infection. All animals achieved and maintained viral suppression (plasma RNA less than 50 copies/mL) through week 67 when they received 10 to 19 doses of either GS-9620 or GS-986 every other week.
TLR7 agonist dosing induced transient and variable increases in plasma SIV RNA levels across all treatment groups. After completing all doses of TLR7 agonist and prior to stopping ART, peripheral lymphocytes and lymph node biopsies from the animals had less inducible virus. Two of the TLR7 agonist-treated rhesus macaques maintained undetectable plasma viral load for more than 90 days after stopping ART.
“Today’s preliminary results give us deeper insight into how we might use GS-9620 effectively as we continue to focus on the potential role of TLR7 agonists in HIV eradication strategies,” said Norbert W. Bischofberger, PhD, Gilead’s Executive Vice President, Research and Development and Chief Scientific Officer. “We have advanced research on GS-9620 to a Phase 1b safety study in HIV-infected individuals taking ART and other GS-9620 studies are also underway, including one in patients with chronic hepatitis B for its potential to reduce HBsAg.”
The proprietary TLR7 agonist compounds GS-9620 and GS-986 are investigational agents, and their safety and efficacy have not been established.
About Gilead Sciences
Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company’s mission is to advance the care of patients suffering from life-threatening diseases. Gilead has operations in more than 30 countries worldwide, with headquarters in Foster City, California.
This press release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks, uncertainties and other factors. In addition, we may observe unfavorable results from clinical trials involving proprietary investigational TLR7 agonists, including GS-9620 and GS-986, as part of an HIV eradication strategy. In addition, Gilead may make a strategic decision to discontinue development of GS-9620 and other proprietary investigational TLR7 agonists if, for example, Gilead believes commercialization will be difficult relative to other opportunities in its pipeline. As a result, GS-9620 and other proprietary investigational TLR7 agonists may never be successfully commercialized. These risks, uncertainties and other factors could cause actual results to differ materially from those referred to in the forward-looking statements. The reader is cautioned not to rely on these forward-looking statements. These and other risks are described in detail in Gilead’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2015, as filed with the U.S. Securities and Exchange Commission. All forward-looking statements are based on information currently available to Gilead, and Gilead assumes no obligation to update any such forward-looking statements.
For more information on Gilead Sciences, please visit the company’s website at www.gilead.com , follow Gilead on Twitter ( @GileadSciences ) or call Gilead Public Affairs at 1-800-GILEAD-5 or 1-650-574-3000.
Gilead Sciences, Inc.
Patrick O’Brien, 650-522-1936 (Investors)
Ryan McKeel, 650-377-3548 (Media)
Om Business Wire
Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.
Følg saker fra Business Wire
Registrer deg med din epostadresse under for å få de nyeste sakene fra Business Wire på epost fortløpende. Du kan melde deg av når som helst.
Siste saker fra Business Wire
Cognitec Brings Unique Video Investigation Features to Face Recognition Product for Law Enforcement14.12.2017 09:38 | Pressemelding
Cognitec Systems, the face recognition company, has significantly extended the feature set of its FaceVACS-DBScan product. The latest release combines the company’s renowned image database search technology with powerful video inspection tools for a multitude of investigation use cases. FaceVACS-DBScan LE enables fast import of video footage and detailed investigations of the extracted facial images. Agents can find known or unknown persons in multiple videos to quickly narrow down suspect investigations. The investigation can reveal, for example, if a suspect was seen in various locations within a set time window, always with the same group of persons, or in one location too many times during the day. With one click, the investigator can add the facial image seen in a video frame to a local database. If a person is already known, the technology can quickly compare
The Idle Man Signs Extension with Radial to Support International Business Growth14.12.2017 08:00 | Pressemelding
Radial, the leader in omnichannel commerce technology and operations, today announced London-based menswear fashion retailer, The Idle Man, has signed an extension with Radial to support its international growth and expansion plans. The extension follows Radial’s ability to quickly launch fulfilment, international shipping, and customer service solutions on behalf of The Idle Man from its U.K.-based operations center in Manchester, in just three months. Radial’s services have improved overall customer satisfaction as The Idle Man expands its international footprint. Founded in 2014 by Oliver Tezcan, former menswear buying manager at Asos.com, The Idle Man was established to fill the gap left by mainstream retailers for fashionable men’s clothing at affordable prices. Quickly becoming the third largest menswear destination in the U.K., with over 1.5 million unique visits each mon
SES Drives 5G Satellite Demonstration Testbed Initiative with ESA14.12.2017 07:55 | Pressemelding
SES is expanding its efforts to support 5G developments as part of ESA’s ARTES project, SATis5, where it will be enabling demonstrations of satellite-terrestrial integration for 5G networks. This press release features multimedia. View the full release here: http://www.businesswire.com/news/home/20171213006286/en/ SES Drives 5G Satellite Demonstration Testbed Initiative with ESA (Photo: Business Wire) The testbed infrastructure will comprise SES's fleet of Geostationary Earth Orbit (GEO) and Medium Earth Orbit (MEO) satellites, which will be integrated with terrestrial networks and state-of-the-art technologies. In addition to providing the space segment, SES's headquarters in Luxembourg will also host a SATis5 testbed node with prototypes of networks for satellite integration, along with other nodes located in Berlin and Erlangen, and an additional portable no
Alibaba Cloud Becomes the First Cloud Computing Company to Obtain C5 Attestation with Additional Requirements14.12.2017 07:00 | Pressemelding
Alibaba Cloud, the cloud computing arm of the Alibaba Group, announced today that it had completed its assessment for the Cloud Computing Compliance Controls Catalogue (C5) set out by the Federal Office for Information Security in Germany, also known as Bundesamt für Sicherheit in der Informationstechnik (BSI). Alibaba Cloud is the world’s first cloud provider to achieve this attestation with the additional requirements. The attestation covers Elastic Compute Service (“ECS”), Relational Database Service (“RDS”), Object Storage Service (“OSS”), Content Delivery Network (“CDN”), Server Load Balancer (“SLB”), Virtual Private Cloud (“VPC”) and Alibaba Cloud Security available on Alibaba Cloud’s regions in Singapore and Germany. This press release features multimedia. View the full release here: http://www.businesswire.com/news/home/20171213006271/en/ Alibaba Cloud becomes t
Alps Electric to Exhibit at Major Chinese Trade Show ELEXCON 201714.12.2017 06:00 | Pressemelding
Japanese electronic components manufacturer Alps Electric Co., Ltd. (TOKYO:6770) (President: Toshihiro Kuriyama; Head Office: Tokyo) will exhibit at ELEXCON 2017, to be held at the Shenzhen Convention & Exhibition Center in Shenzhen, China, from December 21. The company will introduce a wide range of technologies, particularly in the Internet of Things (IoT) domain. This press release features multimedia. View the full release here: http://www.businesswire.com/news/home/20171213005033/en/ Alps Electric Booth Design (Graphic: Business Wire) At ELEXCON 2017, one of China’s largest electronics expositions, Alps Electric will showcase technologies and solutions targeting each of the Internet of Things (IoT), Mobile and Automotive markets. Exhibit Highlight: IoT Sensor Network Module A sensor module for collecting a variety of data,
Photo Press Release: Giant Gingerbread Burj Khalifa Unveiled at DXB14.12.2017 05:57 | Pressemelding
A 14 metre tall Burj Khalifa made of gingerbread takes centre stage at Dubai Airports’ Winter Wonderland DXB now open at Dubai International’s Terminal 3, B gates. “ Winter Wonderland DXB is the perfect way to get in the festive spirit just moments before jumping on a plane. An instagrammable village scene, set right in the middle of the airport, with entertainment for children and adults, visits from the main man in red on his sleigh and more!” said Helen Mellor-Mitchell, VP Media and Brand Engagement, Dubai Airports. This press release features multimedia. View the full release here: http://www.businesswire.com/news/home/20171213006275/en/ Winter Wonderland DXB arrives at Dubai International Airport (Photo: AETOSWire) Editors Notes Dubai Airports manages the operation and development of both of
I vårt presserom finner du alle våre siste saker, kontaktpersoner, bilder, dokumenter og annen relevant informasjon om oss.Besøk vårt presserom