Business Wire

Final results from landmark DYNAGITO® trial published in The Lancet Respiratory Medicine1

Del

Boehringer Ingelheim today announced data from the landmark 52-week DYNAGITO® trial which show that in people with COPD (chronic obstructive pulmonary disease), Spiolto® Respimat® (tiotropium/olodaterol 5/5µg) lowers the rate of moderate-to-severe exacerbations compared with Spiriva® Respimat® (tiotropium). The pre-specified significance level of p<0.01 for the primary endpoint of DYNAGITO® was not met.1 Treatment with tiotropium/olodaterol resulted in a 7% lower rate of moderate-to-severe COPD exacerbations compared with tiotropium alone (p=0.0498).1 This study, involving more than 7,800 people with COPD over 1 year, was published today in The Lancet Respiratory Medicine.1

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20180329005455/en/

Importance of Preventing COPD Exacerbations (Infographic: Business Wire)

Importance of Preventing COPD Exacerbations (Infographic: Business Wire)

“The results of DYNAGITO® are of value, as they show that tiotropium/olodaterol can lower the rate of moderate-to-severe exacerbations in many patients compared to tiotropium – a tough comparator which has consistently demonstrated exacerbation risk reduction through long-term, real-world experience,” said study investigator Professor Peter M.A. Calverley, Professor of Pulmonary Medicine, University of Liverpool, UK. “These data support evidence-based expert recommendations that dual bronchodilator LAMA/LABA therapy has a central role in the management of people with COPD, in terms of symptom improvement and exacerbation risk reduction.”7

COPD is a progressive, yet treatable condition that significantly impacts patients’ lives, restricting their daily activities from early on in the disease.8,9,10 COPD exacerbations, or flare-ups, are sudden episodes of increased breathlessness, cough and mucus production that can last for several days or even weeks.11 These episodes can be seriously disabling, resulting in a need for urgent medical care, including hospitalisation, and sometimes lead to death.11

Further DYNAGITO® data demonstrated that tiotropium/olodaterol was associated with fewer moderate-to-severe exacerbations that needed intervention with a systemic corticosteroid, with or without antibiotics, compared with tiotropium:1*

  • A 20% lower rate of moderate-to-severe exacerbations that required treatment with a systemic corticosteroid (p=0.0068).1*
  • A 9% lower rate of exacerbations where the use of both a systemic corticosteroid and antibiotics were needed (p=0.0447).1*
  • No difference was observed in the rate of exacerbations that required treatment with antibiotics only (p=0.2062).1*

No new side effects or safety concerns were identified in the DYNAGITO® study.1 These data also show that tiotropium/olodaterol has a similar safety profile to tiotropium.1

Reducing symptoms and the future risk of exacerbations are key treatment goals for COPD.7 According to the international GOLD 2018 Strategy recommendations, LAMA/LABA treatments such as tiotropium/olodaterol play a central role in the management of COPD and help to achieve these treatment goals.7

Intended audiences:
This press release is issued from our Corporate Headquarters in Ingelheim, Germany and is intended to provide information about our global business. Please be aware that information relating to the approval status and labels of approved products may vary from country to country, and a country-specific press release on this topic may have been issued in the countries where we do business.

For references and notes to editors, please visit: http://www.boehringer-ingelheim.com/press-release/results-landmark-dynagito-trial

* The pre-specified significance level of p<0.01 for the primary endpoint of DYNAGITO® was not met
Global Initiative for Chronic Obstructive Lung Disease

Contact information

Boehringer Ingelheim
Corporate Communications
Media + PR
Dr. Carolin Grob
Email: carolin.grob@boehringer-ingelheim.com
Phone: +49 (6132) 77-182603
Fax: +49 (6132) 77-6601
or
Email: press@boehringer-ingelheim.com

Om Business Wire

Business Wire
Business Wire
24 Martin Lane
EC4R 0DR London

+44 20 7626 1982http://www.businesswire.co.uk

(c) 2018 Business Wire, Inc., All rights reserved.

Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.

Følg saker fra Business Wire

Registrer deg med din epostadresse under for å få de nyeste sakene fra Business Wire på epost fortløpende. Du kan melde deg av når som helst.

Siste saker fra Business Wire

Dataiku Raises $101 Million Series C to Transform and Democratize Enterprise AI Globally19.12.2018 15:00Pressemelding

Dataiku Inc., one of the world’s leading enterprise data science and machine learning platforms, today announced a $101 million Series C funding round led by ICONIQ Capital and supported by Alven Capital, Battery Ventures, Dawn Capital, and FirstMark Capital. This announcement follows the company’s $28 million Series B in September 2017 and the release of Dataiku 5 in September 2018. Since its founding in 2013, Dataiku has focused on the vision of democratized data science as the key to uninhibited possibilities instead of restricted technologies reserved for the elite few. Today, Dataiku provides a platform that enables enterprises to fundamentally transform their business - global leaders use it to build AI that optimizes marketing budget, enables maintenance services, anticipate market trends or detects fraud, and more. “We’re very excited about what this latest funding round represents - it’s a confirmation of our vision to build and deliver the missing block for the modern enterpr

Universal Laser Systems Expands Its Materials Database with AOK Technologies, Solvay and 3M Materials19.12.2018 13:05Pressemelding

Universal Laser Systems (ULS) announces the addition of AOK Technologies, Solvay and 3M™ materials to its materials database, the most extensive repository of laser material processing parameters for materials in the range of 10 watts to 500 watts. The AOK Technologies, Solvay, and 3M materials new to the ULS materials database were specifically added for laser processing with the ULTRA and XLS platforms, suited for high accuracy and precision laser cutting, laser ablation and laser surface modification. The materials include: AOK Technologies TCK6 Thermally Conductive Insulator AOK Technologies TC1200 Thermally Conductive Insulator Solvay Udel® P-1700 Polysulfone (PSU) Solvay Ajedium™ Film Ultem® 1000-1000 Polyetherimide (PEI) 3M™ 1538L Rayon Acetate Woven Fabric Medical Tape Laser processing notes, describing the results of the laser-material interaction for these materials, are also available in the Materials Library on the ULS website to help potential customers explore the advanta

Gilead Sciences and Scholar Rock Announce Strategic Collaboration to Develop Novel Therapies for Fibrotic Diseases19.12.2018 13:01Pressemelding

Gilead Sciences, Inc. (NASDAQ: GILD) and Scholar Rock Holding Corporation (NASDAQ: SRRK) announced today that the companies have entered into a strategic collaboration to discover and develop highly specific inhibitors of transforming growth factor beta (TGFβ) activation for the treatment of fibrotic diseases. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20181219005363/en/ Under the collaboration, Gilead has exclusive options to license worldwide rights to product candidates that emerge from three Scholar Rock TGFβ programs: inhibitors that target activation of latent TGFβ1 with high affinity and specificity, inhibitors that selectively target activation of latent TGFβ1 localized to extracellular matrix, and a third TGFβ discovery program. Scholar Rock is responsible for antibody discovery and preclinical research through product candidate nomination, after which, upon exercising the option for a program, Gilead will be resp

Boeing-Leonardo Team Selects FLIR Systems EO/IR Surveillance Sensors for US Strategic Command UH-1N Replacement Contract19.12.2018 13:00Pressemelding

FLIR Systems, Inc. (NASDAQ: FLIR) announced today it has been selected by Boeing to provide the FLIR Star SAFIRE 380-HDc EO/IR surveillance sensor for the United States Air Force (USAF) UH-1N replacement contract. The replacement program will replace the current fleet of USAF UH-1N helicopters, which support the service’s nuclear intercontinental ballistic missile bases in Wyoming, Montana and North Dakota. The aircraft will also be used for training, test and operational support airlift missions. The initial contract award to FLIR is for the first four helicopters, with the total contract up to 84 MH-139 helicopters and valued at more than $40 million to FLIR. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20181219005203/en/ FLIR will provide its Star SAFIRE 380-HDc airborne surveillance camera as part of the Boeing-Leonardo UH-1N replacement contract (Photo: Business Wire) Boeing was awarded a $375.5 million firm-fixed-price

BOC Group Listed as a Representative Vendor in the 2018 Gartner Market Guide for Enterprise Business Process Analysis19.12.2018 12:00Pressemelding

The leading global provider of Enterprise Management Solutions, BOC Group, is pleased to share its recognition for its BPM suite ADONIS NP, in Gartner's latest Market Guide for Enterprise Business Process Analysis * . Thereby, BOC Group continues its recognition from the October 2018 Gartner Magic Quadrant and Critical Capabilities for Enterprise Architecture Tools reports for its EA suite ADOIT. Tobias Rausch, ADONIS product manager comments: “We are happy about getting recognized by Gartner, for the second time now, in their recently published Market Guide for Enterprise Business Process Analysis report. We see our placement in this year’s Market Guide as a testimony to our cutting-edge Business Process Analysis offering, and a validation that our strong focus on BPA is helping businesses in the digital transformation of their enterprise.” The Business Transformation Suite ADONIS NP is BOC Group's flagship product and Business Process Management and Analysis tool. This fully web-base

Slice Launch Studio Opens to Insurers and Tech Companies to Create Digital Insurance Products19.12.2018 12:00Pressemelding

Slice Labs Inc., a leading on-demand insurance cloud platform provider, announced today the opening of the Slice Launch Studio in downtown Toronto, which is designed to be an innovation hub for Slice and its partners to ideate, experiment, test and deploy new on-demand insurance products on the Slice Insurance Cloud Services (ICS) platform. Insurers and technology companies from around the world can come to the Launch Studio to collaborate on Hackathons, a key step in Slice’s approach to getting product to market quickly. Slice will also host events year-round, bringing together thought leaders from across the globe to discuss and address emerging and increasing risks. Slice is currently working with insurers in the U.S., Canada, UK and SE Asia to launch new on-demand insurance products, using a minimum viable product methodology which allows for launch in under three months. The Co-operators Group is the pilot partner for the Launch Studio, who recently launched duuo, both its new dig