ERS 2015: Landmark year for Boehringer Ingelheim’s respiratory portfolio - new data for COPD, IPF and asthma treatments
21.9.2015 06:00 | Business Wire
Boehringer Ingelheim will present new data from its broad respiratory portfolio, which includes recently approved Spiolto® Respimat® (tiotropium/olodaterol) for COPD, OFEV® (nintedanib) for IPF and Spiriva® Respimat® (tiotropium) in asthma, at the upcoming European Respiratory Society (ERS) International Congress, 26-30 September.
“With the first approvals of OFEV® and Spiolto® Respimat®, 2015 marks a pivotal year for the company and our ongoing commitment to developing innovative solutions for patients with respiratory diseases,” said Dr William Mezzanotte, Vice President and Head of Respiratory Medicine at Boehringer Ingelheim. “The data to be presented at ERS 2015 add to the growing body of evidence across our portfolio and help to further characterise the efficacy and safety of our medicines to support physicians and patients alike.”
COPD: Spiolto ® Respimat ®
In COPD, the latest results from the Spiolto® Respimat® clinical trial programme include the ENERGITO® Phase IIIb head-to-head study investigating lung function improvements versus the long acting beta2 agonist/inhaled corticosteroid (LABA/ICS) combination salmeterol + fluticasone propionate.1 ICS therapies are only recommended by the GOLD guidelines for use in patients with more severe lung function impairment (GOLD 3/4) and at high risk of exacerbations,4 but they can be associated with potential serious side effects; 5,6,7,8,9 there is therefore debate surrounding their widespread use in the management of COPD.
In addition, a sub-analysis of the recently published OTEMTO® 1&2 trial results2 will compare quality of life benefits of Spiolto® Respimat® in patients at different stages of the disease. The OTEMTO® 1&2 trials showed that the lung function improvements provided by Spiolto® Respimat® translate into symptomatic benefits and clinically meaningful quality of life improvement.10 Spiolto® Respimat® has gained approval in over 20 EU countries for use in the treatment of patients with COPD.
These trials are part of the 15,000 patient TOviTO® Phase III clinical trial programme investigating the efficacy and safety of Spiolto® Respimat® in COPD and build on the pivotal phase III TONADO® trials that demonstrated Spiolto® Respimat® provides significant improvements in lung function, breathlessness, quality of life and reduction in rescue medication use over Spiriva® Respimat®.11
COPD: Spiriva ® and Spiriva ® Respimat ®
Exacerbation history is an important stratifying parameter in COPD4, and as a leader in Respiratory, Boehringer Ingelheim continues analysing large pools of data from its landmark trials to investigate this key consideration. New results from a post-hoc analysis of the TIOtropium Safety and Performance In Respimat® (TIOSPIR™) trial12 will be presented to determine whether exacerbation history (greater than or equal to 1 exacerbation in the past year) and inhaled corticosteroid (ICS) use at baseline affected outcomes of patients with COPD.
OFEV ® (nintedanib) in Idiopathic Pulmonary Fibrosis (IPF)
Monitoring the long-term efficacy and safety of OFEV® (nintedanib) is important for a progressive disease like idiopathic pulmonary fibrosis (IPF). As IPF is a life-threatening and progressive disease, patients will be on long-term treatment to manage their disease. It is important to assess and continue to monitor the efficacy and safety of OFEV® in these patients. New data from the INPULSIS® extension trial (INPULSIS®-ON) will be presented for the first time demonstrating that the efficacy and safety of OFEV® is sustained long-term.13
Further analyses from the two INPULSIS® Phase III clinical trials will also be shared with the respiratory community including the effect of OFEV® on slowing disease progression in patients who were taking anti-acid or corticosteroid medications at treatment baseline.14,15 Anti-acid medications are commonly given to patients with IPF to manage gastroesophageal reflux disease (GERD), a highly prevalent condition in IPF.16
Asthma: Spiriva ® Respimat ®
Highlights from the accepted ERS abstracts include further analysis of data from the two MezzoTinA-asthma® clinical trials to see whether the impact of adding Spiriva® Respimat® to at least ICS maintenance therapy on improvements in lung function is influenced by whether or not the patients are receiving a LTRA* at baseline.3
These new data will add to the existing evidence from the UniTinA-asthma® large-scale, Phase III clinical trial programme that has shown the efficacy and safety of Spiriva® Respimat® in patients with asthma who continue to experience symptoms despite treatment with at least ICS with or without LABA therapy.17,18
Boehringer Ingelheim events at ERS 2015:
Alongside abstract presentations at ERS 2015, Boehringer Ingelheim is hosting a media briefing on September 28 (12.45-14.00 CET, Industry Press Briefing Room, ERS Press Centre) and will be holding the following symposia:
- COPD symposium: Meeting the patient’s needs in the changing world of COPD management September 27 (17:15-19:15 CET, Auditorium)
- Symptomatic asthma symposium: The challenge of treating uncontrolled asthma at Step 3 and higher: Comparing options September 28 (17:15-19:15 CET, Room 4.2)
- IPF symposium: Idiopathic pulmonary fibrosis – where real world meets science September 28 (17:15-19:15 CET, Elicium 1)
- COPD symposium: Profiles of COPD and what can be achieved with treatment September 29 (17:15 – 19:15 CET, Elicium 1)
*Leukotriene receptor antagonist
For ‘Notes to Editors’ and ‘References’ please visit: http://www.boehringeringelheim.com/news/news_releases/press_releases/2015/21_september_2015_Respiratory.html
Media + PR
Dr Kristin Jakobs
Phone: +49 151 6894 7444
Fax: +49 (6132) 77 6601
Om Business Wire
Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.
Følg saker fra Business Wire
Registrer deg med din epostadresse under for å få de nyeste sakene fra Business Wire på epost fortløpende. Du kan melde deg av når som helst.
Siste saker fra Business Wire
IBC’s Big Screen to Explore the Future of Camera and Display Technologies and the Business Behind Cinema22.8.2017 16:58 | Pressemelding
IBC today announced the details of its Big Screen programme, taking place in a specially built auditorium designed to IBC’s specifications and featuring the very latest in cinema technology. With the latest Dolby Vision dramatic imaging and Dolby Atmos immersive audio sound installation, the four-day programme examines and demonstrates the hottest topics, themes, and insights surrounding the art, science, and business of cinema - from capture through to exhibition. As well as being the home of the Big Screen programme, the auditorium will screen in Dolby Vision and Dolby Atmos, Baby Driver, the acclaimed Edgar Wright feature from 2017. The programme for 2017, which has been shaped by a committee of global industry professionals, is an insightful examination of the future of cinema. From virtual reality in cinema to laser and camera assessments, visitors will get up to speed
Digi Communications N.V. Announces the Publishing of an Update to the Investigation by the Romanian National Anti-Corruption Directorate22.8.2017 16:38 | Pressemelding
In connection with the investigation triggered by the Romanian National Anti-Corruption Directorate (“DNA”), which we have previously disclosed to the market and to our investors in the initial public offering prospectus dated 26 April 2017, in the supplemental prospectus dated 8 May 2017 (together, the “Prospectus”), as well as in the subsequent public reports, we inform you that, based on the public release no 832/VIII/3 issued on 22 August 2017, the DNA sent to court under the judiciary control Mr. Ioan Bendei (Vice-president of the Board of Directors of RCS & RDS S.A. – the Company’s subsidiary („RCS&RDS”)) in connection with the offences of bribery and accessory to money laundering, as well as RCS&RDS in connection with the offences of bribery and money laundering, INTEGRASOFT S.R.L. (one of RCS&RDS’s subsidiaries in Romania) in connection with the offence of accessory to mon
SailPoint Named a Leader in Cloud-based Identity Governance22.8.2017 14:00 | Pressemelding
SailPoint, the leader in enterprise identity management, was recently named the overall market leader in KuppingerCole’s 2017 “Leadership Compass: Identity as a Service: Cloud-based Provisioning, Access Governance and Federation.” In addition to being named a leader in every category of the report, SailPoint received superior rankings in four of the five evaluation criteria: security, functionality, interoperability and usability. KuppingerCole is an international and independent analyst organization with a strong focus on Information Security and Identity and Access Management. KuppingerCole’s Leadership Compass reports provide an in-depth analysis of the main players in the market, defining each as a follower, challenger or leader. The Leadership Compass Report for IDaaS evaluates leaders in innovation, product features, and market reach for identity-as-a-service offerings tar
Meggitt Training Systems to Exhibit at DSEI 201722.8.2017 14:00 | Pressemelding
Meggitt Training Systems, the leading provider of integrated live-fire and virtual weapons training products and services for armed forces and law enforcement, will participate at Defence and Security Equipment International (DSEI) through the Georgia Department of Economic Development. The military and security industry event will be held September 12-15, 2017 at ExCeL in London, England. “Today’s threats necessitate maximum realism, despite stretched budgets, and that’s what Meggitt provides to government and commercial customers globally,” said Mark Mears, managing director at Meggitt Training Systems, Ltd. “Although proudly based in Georgia, Meggitt Training Systems is part of Meggitt PLC, a UK-headquartered corporation. As such, we particularly look forward to engaging with current and prospective customers at DSEI, the UK’s largest defense and security trade show.” On
Camelbay Real Estate Management NL B.V. Selects Yardi Voyager22.8.2017 13:58 | Pressemelding
Camelbay Real Estate Management NL B.V. will utilise Yardi Voyager® 7S, a browser-agnostic, fully mobile Software-as-a-Service platform, as its accounting and property management platform. Camelbay will use Yardi Voyager to streamline its property management, leasing and accounting processes for its Dutch real estate portfolio, which is predominantly comprised of commercial office assets. “The automation, transparency and fully integrated accounting and property management that Voyager provides will help us manage our daily financial and operational activities more efficiently and enhance our competitive position within the Dutch office market,” said Alon Levy, Director of Camelbay Real Estate Management NL B.V. “We are very pleased to welcome Camelbay as our latest client in the Netherlands,” said Neal Gemassmer, Vice President of International for Yardi.
Laser Design CyberGage®360, Automated 3D Scanning & Inspection System Adopted by Proto Labs in their State-of-the-Art Metrology Lab22.8.2017 13:44 | Pressemelding
Laser Design, Inc., a subsidiary of CyberOptics (NASDAQ:CYBE), and premier provider of ultra-precise 3D scanning systems and services, announces the adoption of the CyberGage360 3D Scanning and Inspection system by Proto Labs, the world’s fastest digital manufacturing source for custom prototypes and low-volume production parts providing unprecedented speed-to-market value for designers and engineers. “At Proto Labs, we strive to challenge the traditional rules of manufacturing in order to deliver custom manufactured components at unprecedented speeds,” said Dylan Lundberg, Senior Manufacturing Engineer of Protoworks, Proto Labs’ R&D lab. “Everything we do revolves around reducing our customers’ time to market and we do that by digitalizing the entire manufacturing process. From our front-end services to our proprietary processes on the manufacturing floor, you will find thr
I vårt presserom finner du alle våre siste saker, kontaktpersoner, bilder, dokumenter og annen relevant informasjon om oss.Besøk vårt presserom