ERS 2015: Landmark year for Boehringer Ingelheim’s respiratory portfolio - new data for COPD, IPF and asthma treatments
Boehringer Ingelheim will present new data from its broad respiratory portfolio, which includes recently approved Spiolto® Respimat® (tiotropium/olodaterol) for COPD, OFEV® (nintedanib) for IPF and Spiriva® Respimat® (tiotropium) in asthma, at the upcoming European Respiratory Society (ERS) International Congress, 26-30 September.
“With the first approvals of OFEV® and Spiolto® Respimat®, 2015 marks a pivotal year for the company and our ongoing commitment to developing innovative solutions for patients with respiratory diseases,” said Dr William Mezzanotte, Vice President and Head of Respiratory Medicine at Boehringer Ingelheim. “The data to be presented at ERS 2015 add to the growing body of evidence across our portfolio and help to further characterise the efficacy and safety of our medicines to support physicians and patients alike.”
COPD: Spiolto ® Respimat ®
In COPD, the latest results from the Spiolto® Respimat® clinical trial programme include the ENERGITO® Phase IIIb head-to-head study investigating lung function improvements versus the long acting beta2 agonist/inhaled corticosteroid (LABA/ICS) combination salmeterol + fluticasone propionate.1 ICS therapies are only recommended by the GOLD guidelines for use in patients with more severe lung function impairment (GOLD 3/4) and at high risk of exacerbations,4 but they can be associated with potential serious side effects; 5,6,7,8,9 there is therefore debate surrounding their widespread use in the management of COPD.
In addition, a sub-analysis of the recently published OTEMTO® 1&2 trial results2 will compare quality of life benefits of Spiolto® Respimat® in patients at different stages of the disease. The OTEMTO® 1&2 trials showed that the lung function improvements provided by Spiolto® Respimat® translate into symptomatic benefits and clinically meaningful quality of life improvement.10 Spiolto® Respimat® has gained approval in over 20 EU countries for use in the treatment of patients with COPD.
These trials are part of the 15,000 patient TOviTO® Phase III clinical trial programme investigating the efficacy and safety of Spiolto® Respimat® in COPD and build on the pivotal phase III TONADO® trials that demonstrated Spiolto® Respimat® provides significant improvements in lung function, breathlessness, quality of life and reduction in rescue medication use over Spiriva® Respimat®.11
COPD: Spiriva ® and Spiriva ® Respimat ®
Exacerbation history is an important stratifying parameter in COPD4, and as a leader in Respiratory, Boehringer Ingelheim continues analysing large pools of data from its landmark trials to investigate this key consideration. New results from a post-hoc analysis of the TIOtropium Safety and Performance In Respimat® (TIOSPIR™) trial12 will be presented to determine whether exacerbation history (greater than or equal to 1 exacerbation in the past year) and inhaled corticosteroid (ICS) use at baseline affected outcomes of patients with COPD.
OFEV ® (nintedanib) in Idiopathic Pulmonary Fibrosis (IPF)
Monitoring the long-term efficacy and safety of OFEV® (nintedanib) is important for a progressive disease like idiopathic pulmonary fibrosis (IPF). As IPF is a life-threatening and progressive disease, patients will be on long-term treatment to manage their disease. It is important to assess and continue to monitor the efficacy and safety of OFEV® in these patients. New data from the INPULSIS® extension trial (INPULSIS®-ON) will be presented for the first time demonstrating that the efficacy and safety of OFEV® is sustained long-term.13
Further analyses from the two INPULSIS® Phase III clinical trials will also be shared with the respiratory community including the effect of OFEV® on slowing disease progression in patients who were taking anti-acid or corticosteroid medications at treatment baseline.14,15 Anti-acid medications are commonly given to patients with IPF to manage gastroesophageal reflux disease (GERD), a highly prevalent condition in IPF.16
Asthma: Spiriva ® Respimat ®
Highlights from the accepted ERS abstracts include further analysis of data from the two MezzoTinA-asthma® clinical trials to see whether the impact of adding Spiriva® Respimat® to at least ICS maintenance therapy on improvements in lung function is influenced by whether or not the patients are receiving a LTRA* at baseline.3
These new data will add to the existing evidence from the UniTinA-asthma® large-scale, Phase III clinical trial programme that has shown the efficacy and safety of Spiriva® Respimat® in patients with asthma who continue to experience symptoms despite treatment with at least ICS with or without LABA therapy.17,18
Boehringer Ingelheim events at ERS 2015:
Alongside abstract presentations at ERS 2015, Boehringer Ingelheim is hosting a media briefing on September 28 (12.45-14.00 CET, Industry Press Briefing Room, ERS Press Centre) and will be holding the following symposia:
- COPD symposium: Meeting the patient’s needs in the changing world of COPD management September 27 (17:15-19:15 CET, Auditorium)
- Symptomatic asthma symposium: The challenge of treating uncontrolled asthma at Step 3 and higher: Comparing options September 28 (17:15-19:15 CET, Room 4.2)
- IPF symposium: Idiopathic pulmonary fibrosis – where real world meets science September 28 (17:15-19:15 CET, Elicium 1)
- COPD symposium: Profiles of COPD and what can be achieved with treatment September 29 (17:15 – 19:15 CET, Elicium 1)
*Leukotriene receptor antagonist
For ‘Notes to Editors’ and ‘References’ please visit: http://www.boehringeringelheim.com/news/news_releases/press_releases/2015/21_september_2015_Respiratory.html
Media + PR
Dr Kristin Jakobs
Phone: +49 151 6894 7444
Fax: +49 (6132) 77 6601
Om Business Wire
(c) 2018 Business Wire, Inc., All rights reserved.
Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.
Følg saker fra Business Wire
Registrer deg med din epostadresse under for å få de nyeste sakene fra Business Wire på epost fortløpende. Du kan melde deg av når som helst.
Siste saker fra Business Wire
H.I.G. Capital Announces the Sale of KidsFoundation19.7.2018 19:50 | Pressemelding
H.I.G. Capital (“H.I.G.”), a leading global private equity investment firm with more than €21 billion of equity capital under management, announced today that one of its affiliates has entered a definitive agreement to sell the KidsFoundation Group (“KidsFoundation”), the Dutch market leader in childcare services, to Onex Corporation (“Onex”)(TSX:ONEX). Terms were not disclosed. Headquartered in Almere, the Netherlands, KidsFoundation provides high-quality childcare to nearly 30,000 children between the ages of six weeks and 12 years. H.I.G. created KidsFoundation in 2014 through the acquisition of assets from the estate of Estro Group. During H.I.G.’s ownership, the company has developed strongly with significant capital invested by H.I.G. to create a high-quality childcare offering. H.I.G. worked with KidsFoundation management to optimise the footprint of the company by exiting loss-making locations, introduce new IT systems to drive operational improvement and develop an internal M&
SIG Combibloc Group Holdings S.à r.l.: 2018 Second Quarter Results19.7.2018 16:01 | Pressemelding
We are pleased to announce our quarterly conference call to discuss the results of SIG Combibloc Group Holdings S.à r.l. for the second quarter ended June 30, 2018. Date: Monday, July 23, 2018 Time: 15.00 CEST / 14.00 BST / 9.00 EDT The call information will be distributed on our secure site. If you would like access to our call, please contact email@example.com . Regards, SIG Combibloc Group Holdings S.à r.l. View source version on businesswire.com: https://www.businesswire.com/news/home/20180719005634/en/ Contact information SIG Combibloc Group Holdings S.à r.l. Jennifer Gough firstname.lastname@example.org
NEORIS Announces Creation of Innovation Labs Worldwide to Create a Smarter Future19.7.2018 15:32 | Pressemelding
NEORIS, a global digital consulting services company, announced today it is consolidating the most innovative solutions it has developed in different geographies and allocating unprecedented resources to deploy a network of Innovation Labs worldwide. The main objective is to lay the foundation for the continuous development of disruptive solutions for its four core industries: Manufacturing, Financial Services, Healthcare and Telecommunications. Due to its disruptive nature, NEORIS decided that its first Innovation Lab should be housed in the Monterrey Digital Hub, which today is the first-of-its-kind as it is a space where entrepreneurs, companies, universities and investors converge to foster an ecosystem for Digital Transformation. The lab inaugurated in Monterrey, Mexico is the first of a series of Innovation Labs that will open in the different countries that NEORIS operates, and is a space where customers can experience emerging technologies through real-life scenarios. One such
CORRECTING and REPLACING Albar Capital Deploys FlexNOW19.7.2018 15:29 | Pressemelding
Subhead of release should read: Out-of-the-Box Multi-Asset Execution Management System (instead of Easy-to-Install Multi-Asset Execution Management System). The corrected release reads: ALBAR CAPITAL DEPLOYS FLEXNOW Out-of-the-Box Multi-Asset Execution Management System FlexTrade (@FlexTrade) today announced that Albar Capital Ltd., a new hedge fund led by Javier Velazquez (formerly of Millennium Capital Partners LLP), is now trading equities and futures using FlexNOW, FlexTrade’s new execution management system. “The FlexNOW team was instrumental in solving several of our problems,” said Jason Ruder, Trader at Albar Capital. “Not only are they helping us with our compliance requirements, they are also responsive to requests that improve my workflow.” According to Rhyd Lewis, FlexNOW Product Manager, FlexNOW’s quick onboarding and easy installation process was critical for Albar Capital’s launch on 2 July. “We had no problem integrating FlexNOW with Albar’s portfolio and risk managemen
Full Core of Westinghouse Fuel Achieved at South-Ukraine Nuclear Power Plant Unit 319.7.2018 13:25 | Pressemelding
Westinghouse Electric Company announced today that Ukraine’s State Enterprise National Nuclear Energy Generation Company (SE NNEGC) Energoatom’s South-Ukraine NPP Unit 3 near Yuzhnoukrainsk in Mykolaiv province was loaded with a full core of Westinghouse VVER-1000 fuel. This is the first unit in Ukraine to operate with Westinghouse VVER-1000 fuel assemblies as the sole fuel source. “Westinghouse began supplying fuel to Ukraine in 2005, when the first lead test assemblies were delivered to South-Ukraine Unit 3,” said Aziz Dag, vice president and managing director, Northern Europe. “We are proud to continue supporting Ukraine with their energy diversification by supplying a full core of Westinghouse VVER-1000 fuel to our customer, Energoatom.” Westinghouse currently supplies fuel to six of Ukraine’s 15 nuclear power reactors. Beginning in 2021, the number of reactors with Westinghouse fuel will increase to seven. “Westinghouse has made significant investments over the last several years
Seoul Semiconductor Delivers Its Innovative LED "SunLike" to U.S. Lighting Market19.7.2018 13:00 | Pressemelding
Seoul Semiconductor Co., Ltd. (KOSDAQ:046890), a market leader in LED (light emitting diode) design and manufacturing, announced that its innovative LED “SunLike” is applied to brand new lightings to be launched by three lighting premium brands in U.S., Pure Edge Lighting, LEDRAbrands, Inc. and Elite Lighting. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20180719005377/en/ The product of LEDRAbrands, Inc., NU4RA-SUN, which applied SunLike of Seoul Semiconductor (Photo: Business Wire) Seoul Semiconductor supplies SunLike to pendant lighting for Pure Edge, a U.S. lighting solution company. It is applied to high-end lighting for museums and art galleries that require the highest color quality. The leading lighting design companies, LEDRAbrands, Inc. and Elite Lighting, apply SunLike to downlights and spotlights respectively. “We have selected Seoul Semiconductor’s innovative LED SunLike for our human centric lighting and believ