Business Wire

Boehringer Ingelheim, the UK Cystic Fibrosis Gene Therapy Consortium, Imperial Innovations and Oxford Biomedica Announce New Partnership to Develop First-in-Class Gene Therapy for Cystic Fibrosis

Del

Boehringer Ingelheim, the UK Cystic Fibrosis Gene Therapy Consortium (GTC)—consisting of Imperial College London and the Universities of Oxford and Edinburgh—Imperial Innovations, and Oxford BioMedica (OXB) announce a global collaboration to develop a first-in-class, long-term therapy for patients with cystic fibrosis (CF). The new partnership brings together the academic partners’ leading expertise in developing gene therapy for CF and OXB’s leading expertise in manufacturing lentiviral vector-based therapies with Boehringer Ingelheim’s capabilities in drug discovery and the clinical development of novel breakthrough therapeutic agents.

Cystic fibrosis is a genetic disease that causes persistent lung infections and usually limits a person’s ability to breathe over time. There are more than 2,000 known mutations in the gene for the cystic fibrosis transmembrane conductance regulator (CFTR), many of which result in a person developing CF. The disease is estimated to affect 70,000 people worldwide, with the majority of those located in the US and Europe. Existing treatments and those under development can only slow the progression of disease. As such, CF continues to be associated with considerable morbidity, mortality, and a high burden of therapy. In addition, existing treatments will have varying effects depending on a patient’s mutation status, as determined by the particular gene variation that causes their disease. Thus, there is a critical unmet need for therapies that address all CFTR mutations; gene therapy has the potential to provide such a solution.

The collaboration will focus on a novel approach using a replication-deficient lentiviral vector in an inhaled formulation, to introduce a healthy copy of the CFTR gene into the cells of the lung. This method has demonstrated high gene transfer efficiency and offers the possibility of repeated administration to maintain the therapeutic effect. Gene therapy is the only therapeutic approach to date that can address all CFTR gene mutations, thus potentially offering a universal treatment option.

Professor Eric Alton, Coordinator of the UK Cystic Fibrosis Gene Therapy Consortium, said “The UK CF Gene Therapy Consortium has, for the last 17 years, vigorously sought to establish whether gene therapy can become a clinically viable option for patients with CF. From the beginning the GTC identified that this goal would require incremental increases in knowledge. We have, therefore, built on our non-viral gene therapy experience to develop a new viral vector-based product, which is currently funded by the Health Innovation Challenge Fund (a partnership between the Wellcome Trust and the Department of Health and Social Care) and the Cystic Fibrosis Trust. It is with great pleasure that we now join forces with two world-class organisations. Boehringer Ingelheim will provide its multinational industry expertise, including a rich heritage in the respiratory field, to drive the product towards the clinic, whilst Oxford BioMedica is the acknowledged leader in the field of lentiviral vector manufacturing. The GTC believes that this partnership provides CF patients with the optimal chance to establish gene therapy as routine clinical practice, relevant to all patients, irrespective of their mutation status, and in due course to both prevent lung disease as well as treat established problems. We would like to take this opportunity to warmly thank all of our fundraisers who have supported us over many years.”

“This novel three-way partnership brings together an unparalleled combination of clinical, scientific, manufacturing and commercial skills in an effort to develop new treatments and make a major contribution to the lives of patients affected by cystic fibrosis,” stated John Dawson, Chief Executive Officer of Oxford BioMedica. “The GTC has been working determinedly for over 15 years to get to this exciting point of forming a partnership with Boehringer Ingelheim, a global pharmaceutical company with respiratory expertise. Our contribution to this partnership reaffirms our leading position in the development and manufacturing of lentiviral vector gene therapy products at large scale. We look forward to working with our new academic and industry partners.”

“Through this collaboration, we are joining forces with some of the top talents in this disease space to propel treatment advances forward,” said Clive R. Wood, Ph.D., Senior Corporate Vice President, Discovery Research at Boehringer Ingelheim. “Bringing together our existing expertise as a leader for nearly a century in the discovery and development of therapies that have advanced patient care in respiratory diseases with the gene therapy knowledge of our partners, we aim to unlock unprecedented opportunities for patients with this devastating disease, who are desperately waiting for better treatment options.”

Boehringer Ingelheim has received an option to license the exclusive global rights to develop, manufacture, register, and commercialise this lentiviral vector-based gene therapy for the treatment of cystic fibrosis. Financial terms are not disclosed. During the option period the partners will work closely together to pursue the development of this innovative approach financed by Boehringer Ingelheim. The new collaboration is a joint initiative of Boehringer Ingelheim’s Respiratory Therapeutic Area and Research Beyond Borders (RBB), which is one of the pillars of Boehringer Ingelheim’s research and development strategy and explores emerging science, disease areas and technology. It builds on Boehringer Ingelheim’s commitment to early science and its comprehensive approach to respiratory research and development to investigate new treatments that have significant clinical value in areas of high unmet need.

Andrew Tingey, Director of Healthcare Licensing at Imperial Innovations said, “The UK Cystic Fibrosis Gene Therapy Consortium shows the power of world-class academic groups collaborating to develop advanced potential therapies. We were delighted to have been chosen as the technology transfer partner for the GTC and have worked closely with them during the development of this potential new gene therapy, securing the intellectual property necessary to drive forward its commercial development and to support the collaboration with Boehringer Ingelheim and Oxford BioMedica. The combination of expertise and resources realised by this deal will give the project a unique opportunity to develop an advanced therapy that could significantly impact the lives of thousands of people living with cystic fibrosis, and we are delighted to have played the lead role in securing this partnership.”

Please click on the following link for ‘Notes to Editors’:

http://www.boehringer-ingelheim.com/press-release/new-partnership-develop-gene-therapy-cystic-fibrosis

The information contained within this announcement is deemed by the Company to constitute inside information as stipulated under the Market Abuse Regulation (EU) No. 596/2014. Upon the publication of this announcement via the Regulatory Information Service, this inside information is now considered to be in the public domain.

Media Contacts:

Boehringer Ingelheim
Dr. Reinhard Malin
Head of Communications, Innovation Unit
Boehringer Ingelheim Corporate Center GmbH
Media + PR
P: +49 6132 77-90815
reinhard.malin@boehringer-ingelheim.com

Linda Ruckel
Associate Director, Media and Corporate Reputation
Boehringer Ingelheim US
Media + PR
P: +1 203-791-6672
linda.ruckel@boehringer-ingelheim.com

UK Cystic Fibrosis Gene Therapy Consortium
Imperial College London
Professor Eric Alton
P: +44-207-594-7937
e.alton@ic.ac.uk

Professor Uta Griesenbach
P: +44-207-594-7927
u.griesenbach@ic.ac.uk

Professor Jane Davies
P: +44-207-594-7973
j.c.davies@ic.ac.uk

Tracy Harman
P: +44-207-594-7932
t.harman@ic.ac.uk

University of Oxford
Professor Deborah Gill
P: +44-1865 221845
deborah.gill@ndcls.ox.ac.uk

Associate Professor Stephen Hyde
P: +44-1865 221845
steve.hyde@ndcls.ox.ac.uk

University of Edinburgh
Dr Christopher Boyd
P: +44-131-651-8733
Chris.boyd@ed.ac.uk

Dr Gerry McLachlan
P: +44-131-651-9162
gerry.mclachlan@roslin.ed.ac.uk

Imperial Innovations
+44 (0)20 2053 8850
Gavin Reed
Marketing Manager
Gavin.reed@imperialinnovations.co.uk

David Barreto Ian
Marketing Executive
dbi@imperialinnovations.co.uk

Oxford BioMedica

Oxford BioMedica plc:
John Dawson, Chief Executive Officer
Tel: +44 (0)1865 783 000
Stuart Paynter, Chief Financial Officer

Financial and corporate communications enquiries:
Consilium Strategic Communications
Tel: +44 (0)20 3709 5700
Mary-Jane Elliott/Matthew Neal/Olivia Manser/Laura Thornton

Peel Hunt (Joint Corporate Brokers):
Tel: +44 (0)20 7418 8900
James Steel
Christopher Golden

WG Partners (Joint Corporate Brokers):
Tel: +44 (0)20 3705 9321
David Wilson
Claes Spång

Contact information

Media:
Boehringer Ingelheim
Boehringer Ingelheim Corporate Center GmbH
Media + PR
Dr. Reinhard Malin, +49 6132 77-90815
Head of Communications, Innovation Unit
reinhard.malin@boehringer-ingelheim.com

Om Business Wire

Business Wire
Business Wire
24 Martin Lane
EC4R 0DR London

+44 20 7626 1982http://www.businesswire.co.uk

(c) 2018 Business Wire, Inc., All rights reserved.

Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.

Følg saker fra Business Wire

Registrer deg med din epostadresse under for å få de nyeste sakene fra Business Wire på epost fortløpende. Du kan melde deg av når som helst.

Siste saker fra Business Wire

Interxion Announces Direct Connectivity to Google Cloud Platform across Its European Footprint14.8.2018 08:00Pressemelding

INTERXION HOLDING NV (NYSE: INXN), a leading provider of carrier and cloud-neutral colocation data centre services in Europe, today announced that dedicated access to Google Cloud Platform (GCP) is now available across its European footprint through Cloud Connect, Interxion’s multi-cloud interconnection platform. With Google Cloud deploying its Cloud Interconnect points of presence (PoPs) in Interxion’s Paris, Marseille, Frankfurt and Stockholm data centres, customers can now directly connect to Google Cloud Platform from these locations. Moreover, because Interxion is a partner of Google Cloud’s newly launched Partner Interconnect service, customers can also connect from any of Interxion’s data centres across Europe via Cloud Connect. Customers using this service benefit from fully redundant, instant access to GCP from multiple metropolitan areas, ensuring a 99.99% availability SLA without the complexity and costs of having to build a networking solution themselves. “We are seeing str

Lumileds Wins Jury Verdict of Liability for Intellectual Property Theft Against Elec-Tech International Co., Ltd., Donglei Wang, and Gangyi Chen13.8.2018 22:45Pressemelding

On August 10, 2018, a jury of six men and six women rendered a verdict in favor of one the world’s leading LED companies, Lumileds LLC, based in San Jose, finding that a Chinese competitor stole trade secrets related to Lumileds core technology for making high power LEDs used in flash phones, automotive headlights, and general illumination. The case, Lumileds LLC v. Elec-Tech International Co., Ltd., Donglei “Tony” Wang, and Gangyi Chen, Superior Court of the State of California, County of Santa Clara, found the defendants liable for damages in intellectual property theft. The jury awarded Lumileds $66 million. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20180813005694/en/ Mark Adams, Chief Executive Officer at Lumileds Inc. (Photo: Business Wire) The jury concluded that ETI, Wang and Chen misappropriated Lumileds trade secrets, took them to China, and used them to develop ETI’s LED technology. The award of $66 million is t

Growing Turkish Lira Crisis Drives Investors to Seek Safe Haven in Gold13.8.2018 13:34Pressemelding

The currency crisis engulfing the Turkish Lira is likely to intensify this week as the contagion becomes more widespread around the world. The volatility on the currency exchanges has led investors to pursue the stability offered by safe havens such as gold, which saw a hike in value by 0.4 per cent coinciding with the crash of the Lira. 1 Tom Coughlin, CEO of Kinesis, the bullion backed blockchain monetary system, comments: “The sharp rise in the price of gold seen in the past few days off the back of the Turkish Lira crisis, reflects a rising trend amongst investors wanting to protect their investments, from volatility caused by political instability. This is supplemented by the growing trend of decentralisation which has driven the underlying price of gold up 2% since the start of the year.” Investment in blockchain has doubled in the past year, with 82 per cent of ICO investors citing decentralisation as the main driver behind their investment. 2 Despite this trend, blockchain inve

Seoul Semiconductor’s Innovative SunLike LEDs Earn Industry Recognition in 2018 IES Progress Report13.8.2018 13:00Pressemelding

Seoul Semiconductor (KOSDAQ 046890), a leading global innovator of LED products and technology, has announced that its SunLike Series natural spectrum LEDs, powered by TRI-R, were recognized in the 2018 Illumination Engineering Society (IES) Progress Report, presented on August 10, 2018 at the IES Annual Conference in Boston, MA. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20180813005229/en/ Seoul Semiconductor’s SunLike was recognized in the 2018 IES Progress Report (Graphic: Business Wire) As the recognized technical and educational authority on illumination, IES annually announces significant new advancements in lighting products, research, publications, and design tools in its IES Progress Report. Acceptance is based on an impartial judging process used by the committee to evaluate each submission on its uniqueness, innovation and significance to the lighting industry. SunLike Series natural spectrum LEDs are the world’

Skunkworks Surfing Co. Co-Founders Appointed to be Endowment for Clean Oceans Judges13.8.2018 11:07Pressemelding

The Endowment for Clean Oceans (ECO) announced that Skunkworks Surfing Co. Co-Founders CEO Chris and Ricky Martin have been selected and they have accepted to be ECO judges. Chris will serve on the Science and Tech Committee, and Ricky on the Entrepreneur Committee. An entrepreneur’s survival depends on their ability to execute their technical vision. “They have the sort of innovative entrepreneur and plastic materials technical expertise we are looking for to be ECO judges,” said Daniel Perrin, Founder and CEO of ECO. The role of the Entrepreneur Committee is to judge each entry to ECO’s two contests for scalability and executability. The Scientific and Technical Committee evaluate each entry from that perspective. “We are extremely excited to be part of this important and historic work,” said the Martin brothers. ECO’s contests are simply to provide a $1 million prize for an actionable and scalable plan to remove the micro and macro pieces of plastic from the ocean, and for the $5 mi

GN Hearing Announces Unprecedented Layers of Sound™ and the World’s Most Advanced Rechargeable Hearing Aid Solution13.8.2018 11:00Pressemelding

GN Hearing today unveils the world’s first Premium-Plus hearing aid: ReSound LiNX Quattro™, designed for people who want the very best that technology has to offer and desire a brilliant sound experience with great speech intelligibility even in noisy situations. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20180813005254/en/ Unprecedented Layers of Sound™ and the World’s Most Advanced Rechargeable Hearing Aid Solution (Photo: Business Wire) ReSound LiNX Quattro™ offers a new category of hearing solution and expands GN Hearing’s product portfolio, which already includes the premium ReSound LiNX 3D™ product family. Powered by new technology, including a new chip platform, ReSound LiNX Quattro™ offers a combination of unmatched sound quality and rechargeability, while further expanding GN Hearing’s leadership within 2.4 GHz connectivity and remote fine-tuning: Sound quality: A brilliant sound experience, with clearer, fuller a