Boehringer Ingelheim HCP Survey: Nearly 20% of newly diagnosed lung cancer patients tested for EGFR mutations at risk of missing out on personalised treatments for their disease
Results from a new international survey of physicians revealed more patients with advanced non-small cell lung cancer (NSCLC) could benefit from targeted therapy based on their lung cancer type, over the use of chemotherapy. Test results to identify EGFR mutations were not available prior to deciding on therapy for nearly one in five (18%*) patients for whom a test was ordered. The goal of personalised therapy for all eligible patients remains out of reach for many, despite international guidelines which recommend molecular testing for EGFR mutation and ALK rearrangements in lung cancer patients at diagnosis, to guide treatment decisions. The survey results were presented today as a late-breaking abstract (P3.02b-023) at the 2016 World Conference on Lung Cancer (WCLC) in Vienna, Austria.
Dr. Vera Hirsh, medical oncologist in the Department of Medical Oncology at Royal Victoria Hospital in Montreal, and Professor at McGill University commented, “This survey highlights both encouraging and concerning results for the treatment of first-line non-small cell lung cancer patients. Whilst globally EGFR testing rates were on average high at 80%*, if physicians do not have access to ordered test results prior to first-line treatment this defeats the purpose of such testing. This survey helps us to observe an incomplete implementation of guidelines, which brings forth a significant area of need. Ensuring patients do not miss out on personalised treatment, which could greatly benefit outcomes, is key.”
The survey of 707 physicians in 11 countries (Canada, China, France, Germany, Italy, Japan, South Korea, Spain, Taiwan, UK, USA), sponsored by Boehringer Ingelheim, aimed to identify year-on-year improvements and changes in EGFR mutation testing rates and treatment practices in NSCLC, when compared to an inaugural survey in 2015.
In comparison to 2015, the number of tests ordered but not received prior to first-line treatment decreased (23% in 2015; 18%* in 2016), however treatment decisions were still made before knowing mutation status for one in five patients. Turnaround time for test results could be a key barrier. For the majority of patients tested for EGFR mutations, results were available within 10 business days. However approximately one test result out of every four globally (24%*) was received later, meaning treatment decisions were possibly delayed or not informed by mutation status.
“This international survey helps to bring the current advanced lung cancer treatment landscape into the spotlight, and interestingly track what has and hasn’t changed in the last year,” said Dr. Matthew Peters, Chair of the Global Lung Cancer Coalition (GLCC). “These patients can benefit from targeted treatments, but crucial steps in the treatment pathway are mutation testing in the first instance, receiving accurate test results in time to guide therapy, and understanding the different treatment benefits of available therapies. The key conclusion is that more is needed to support physicians in their goal to improve outcomes for EGFR mutation-positive patients.”
Further findings from the international survey showed that:
- Globally nearly four out of five (79%*) EGFR mutation-positive patients were treated first-line with tyrosine kinase inhibitors (TKIs) in 2016, consistent with 2015 (80%), with large country variances.
- Over half (51%*) of physicians did not differentiate between available EGFR targeted therapies. Recent data has helped physicians make informed treatment decisions between first- and second-generation TKIs.
- Over half (54%*) of physicians deemed prolonging of survival / extending life as the most important goal in first-line treatment, consistent with the primary goal reported in last year’s survey (63%).
- When asked what the most important treatment attribute was when choosing a first-line therapy, 54%* of physicians selected a clinically relevant increase in overall survival, followed by an increase in progression-free survival (18%*), strong improvement of health related quality of life (8%*) and meaningful overall response rate (ORR 8%*).
NSCLC is the most common form of lung cancer, which accounts for 80-85% of all lung cancer cases. EGFR mutation-positive NSCLC is a subtype of lung cancer. EGFR mutations are found in 10-15% of Caucasian and 40-50% of Asian patients with NSCLC. Often, lung cancer is diagnosed at a late stage (advanced) which can make it even more difficult to treat.
*Global figures excluding China.
Intended audiences: This press release is issued from our Corporate Headquarters in Ingelheim, Germany and is intended to provide information about our global business. Please be aware that information relating to the approval status and labels of approved products may vary from country to country, and a country-specific press release on this topic may have been issued in the countries where we do business.
For references and notes to editors, please visit: http://www.boehringer-ingelheim.com/press-release/egfr-treatment-choices-global-survey
For more information, please visit: www.boehringer-ingelheim.com
Further media channels:
Media + PR
Phone: +49 6132 – 77 93319
Fax: +49 6132 – 77 6601
Om Business Wire
Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.
Følg saker fra Business Wire
Registrer deg med din epostadresse under for å få de nyeste sakene fra Business Wire på epost fortløpende. Du kan melde deg av når som helst.
Siste saker fra Business Wire
Bidgely Closes $27M Series C to Grow Artificial Intelligence Solution for Utilities and Energy Retailers16.1.2018 11:00 | Pressemelding
U.S.-based Bidgely announced today the closing of a $27 million Series C round of financing, marking the largest round of investment to date for any energy disaggregation technology. Georgian Partners, an investment fund known for its focus on high-growth enterprise software companies that use applied artificial intelligence to disrupt markets, led the oversubscribed round. Returning investors include Khosla Ventures, E.ON, and innogy. Constellation Technology Ventures, the venture capital arm of Exelon Corporation, is also expected to return. This press release features multimedia. View the full release here: http://www.businesswire.com/news/home/20180116005615/en/ Bidgely Energy Usage Itemisation (Photo: Business Wire) “We invest in high-growth SaaS companies that are applying AI to solve real-world business problems,” said Simon Chong, Managing Partner at Georgian Partners. “Bidgely is using machine learning to fundamentally reinvent customer engagement with utilities and enable a n
Glennmont Seeks More Than 500MW of Investment Opportunities in Clean Energy Infrastructure Assets with Expanded Investment Capacity16.1.2018 10:19 | Pressemelding
Glennmont Partners has expanded its investment capacity in the clean energy infrastructure space and now has three funds under management – these are Fund I (2010) and Fund II (2013), which are fully invested, and now a new third Fund (2017). Opportunities are being sought for a portfolio of clean energy infrastructure projects in Europe. Glennmont is one of Europe’s largest investors focusing exclusively on investment in clean energy infrastructure. This announcement follows the successful refinancing of Glennmont’s 245MW Italian wind portfolio in October and the refinancing of the Sleaford straw-fired biomass plant in September - amounting to around €340m of capital raised over the course of 2017. Glennmont’s strategy remains consistent with its past experiences: it seeks to invest in solar PV, offshore and onshore wind, bioenergy and small-scale hydro across the EEA; it will target to-be-built and recently operational assets with stable, predictable cash yields underpinned by regula
Breed Reply Portfolio of IoT Start-Ups Raise in Excess of $50 Million in Series A Funding in 201716.1.2018 10:00 | Pressemelding
Breed Reply, a leading operational investor in early-stage internet of things (IoT) businesses, saw one third of its 18-strong portfolio of investee companies, complete series A funding rounds in 2017. In total, six companies raised in excess of $50 million during the year with funds coming from notable investors including Accel, Aviva Ventures, Finance Wales, Intu and MunichRE. More companies in the growing portfolio are expected to be ready for Series A investment in 2018. The successful companies span a broad range of IoT sectors: Callsign (Cyber Security); Cocoon (Smart Home); enModus (Smart Building); Senseye (Industrial); WePredict (Big Data); and Zeetta Networks (Platforms). Helping start-ups prepare for future funding is a crucial part of Breed Reply’s commitment to companies when it invests. As an active operational investor, Breed Reply works closely with management to accelerate the company’s development to achieve Series A funding and beyond. The team has significant experi
Japan's 16 Most Mesmerizing Destinations Introduced in a New Live-Action 360-Degree Video16.1.2018 10:00 | Pressemelding
Japan National Tourism Organization (JNTO, London Office) released a 360-degree VR video “[360-degree VR] JAPAN – Where tradition meets the future” on 16 January 2018. The video visualizing the essence of Japan and its culture was created as part of “JAPAN – Where tradition meets the future”, a large-scale inbound tourism promotion targeting 15 European countries, which started in 2016. With the concept of fusing together “tradition,” “innovation,” and “nature” which coexist in the diverse culture of Japan, the 360-degree VR video takes viewers on a virtual tour of Japan. This press release features multimedia. View the full release here: http://www.businesswire.com/news/home/20180116005057/en/ Japan National Tourism Organization's large-scale inbound tourism campaign "JAPAN - Where tradition meets the future" (Photo: Business Wire) As part of the promotion, there will be a social media prize competition to win a round-trip to Japan. Also, an AR digital signage display “Interactive Vis
MagicStay Raises 1.5 Million Euros to Accelerate Its Development16.1.2018 10:00 | Pressemelding
The short-term rental start-up for business travelers MagicStay.com , has just finalized a new round of fundraising to continue its development. Just four years since its release, the rental platform already offers 150,000 apartments in 90 countries and has taken a leading position in the alternative accommodation industry. The fundraising totaling 1.5 million Euros was led by the start-up’s main shareholders (Michaël Benabou, Benoit Bassi, Patrick Lucas, Nicolas Quenedey or Charles Petruccelli, former CEO of American Express Global Business Travel...), as well as new investors, including Marc Frappier, Managing Partner of Eurazeo and Head of Eurazeo Capital, Thibault Basquin, Managing Director of Ardian, Nicolas Santi-Weil, CEO of AMI Paris... This round table will let the start-up accelerate its exclusive technological development for employees of large companies to book secure apartments as easily as hotel rooms, via either existing booking tools (Hotel Booking Tool, Self Booking To
Panasonic Launches New IoT Services with Silicon Valley Startups at CES 2018 Sands Expo16.1.2018 08:42 | Pressemelding
The Automotive & Industrial Systems Company of Panasonic Corporation is challenging to develop new businesses and services in the IoT field, in cooperation with Silicon Valley startups. This press release features multimedia. View the full release here: http://www.businesswire.com/news/home/20180116005839/en/ Panasonic booth at CES 2018 Sands Expo (Photo: Business Wire) [Video] One Touch Home Automation, One Touch ID Authentication | #PanasonicCES 2018 https://youtu.be/dNGulaV1Bx0 Panasonic is advancing the development of new IoT services and solutions by combining leading UI/UX(*1) technology with its strong HMI (human machine interface) design technology, which has been refined through the smartphone switch business and automotive touch panel business. To demonstrate this initiative, Panasonic set up a display booth at CES 2018 (Sands Expo), which took place in Las Vegas, Nevada, US from January 9 (Tuesday) to 12 (Friday), 2018. With the concept of "Touch by Panasonic," solutions fea
I vårt presserom finner du alle våre siste saker, kontaktpersoner, bilder, dokumenter og annen relevant informasjon om oss.Besøk vårt presserom