AMR Industry Alliance: Report Shows Life Sciences Industry Alliance is Taking Action to Curb Antimicrobial Resistance, with More to Come
Today, the AMR Industry Alliance launches its first report that shows the commitment of the life sciences industry to tackle the public health threat of antimicrobial resistance (AMR). The Alliance brings together over 100 biotech, diagnostics, generics and research-based biopharmaceutical companies and trade associations from 20 countries. The report was compiled by SustainAbility. The data and case studies collected in the Alliance report provide unique insights into the practical steps members are taking to respond to AMR in the areas of research and science, access, appropriate use, and the environment. The report presents data on AMR-relevant products, including therapeutic agents or technologies that have the potential to treat or prevent infectious diseases and/or combat resistance, including but not limited to antibiotics, vaccines, diagnostics, and novel approaches to address AMR. The Alliance showcases industry’s efforts and commitment to fulfil its role as a necessary and constructive partner in finding sustainable solutions to tackle AMR.
“This first report is ground-breaking for several reasons,” explains Thomas Cueni, chair of the Alliance. “It is unique in that the companies have committed to walk the talk together and report on their progress. It is the first industry-wide grouping of this scale that has been set up to respond to the AMR emergency.”
This first progress report has aggregated data from 36 companies from all four categories represented in the Alliance: all research-based biopharmaceutical companies (11 out of 11), half of the generics (3 out of 6), one third of diagnostics members (5 out of 15), and one quarter (17 out of 68) of SMEs provided input. The Alliance is committed to reporting progress every two years. It is also dedicated to refining its approach to better address the challenges for its members in responding, so that it can achieve greater participation than seen in this first report.
The submitted data provides considerable insight into private sector efforts to curb AMR and shows that “broadly the Alliance membership is already active and making positive contributions to the challenge of AMR, even though there is a long way to go – on full Alliance participation and greater gains against AMR,” said Denise Delaney from SustainAbility.
Research and science : The report confirms a broad commitment to research by companies in 2016. At least USD 2 billion in R&D was dedicated to AMR-related products in 2016. This is a conservative number as it corresponds to the data provided by only 22 companies. These investments cover R&D-related costs for early-stage R&D exploring new product classes, ten antibiotics in late-stage clinical development, 13 clinical bacterial vaccine candidates, and 18 AMR-relevant diagnostic products, as well as other preventive therapies. A majority of Alliance companies viewed R&D incentives as either “promising but with far to go” or “insufficient relative to the challenge.”
Access: While vast amounts of antimicrobials, especially antibiotics, go to waste on patients and animals who do not need them, almost six million people die each year from infections, because they lack access to these medicines. The Alliance supports protecting the efficacy of antibiotics and making them available, where necessary, to every human being. More than two out of three Alliance companies surveyed with marketed AMR products have strategies, policies or plans in place, which include principles or efforts to improve access to their AMR-relevant products. A similar number of companies are engaged in dialogue with external stakeholders on improving access to their AMR relevant products. Many of the Alliance generics and R&D-based biopharmaceutical companies with AMR-relevant products believe more work is needed to determine how to balance expanding access with appropriate use, reduce falsified products, and work with other stakeholders to address access issues in low and middle income countries.
Appropriate use: Over 80% of all responding companies are engaged in activities to support appropriate use, while nearly half of the responding companies have a formal appropriate use strategy in place. Nearly 90% of responding companies – and 70% of those with AMR-relevant marketed products – are planning to, currently collecting or support the collection of surveillance data. More than half of the responding companies are planning to, or are currently engaged in, stewardship education activities, directly or collaboratively. This number increases to 70% for those companies with a marketed AMR-relevant product. However, it is broadly acknowledged that there is a considerable way to go, and the potential of vaccines and diagnostics is not yet fully explored.
Manufacturing and the environment: Alliance companies, particularly those that made bold commitments in the Roadmap, are taking action to reduce the potential impacts of antibiotics manufacturing on AMR. One third of the Alliance companies that produce antibiotics currently have a strategy, policy or plan in place to address the issue of the release of antibiotics in their own manufacturing effluent that may contribute to AMR. Three quarters of them anticipate the implementation of good practice methods to reduce environmental impact of manufacturing discharge by 2018, well ahead of the 2020 target. The report also features a newly drafted common framework for managing antibiotic discharge across company supply chains.
Progress report: https://www.amrindustryalliance.org/progress-report/
Morgane De Pol
Medicines for Europe
Biotechnology Innovation Organization (BIO)
Danielle M. Blake
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