American College of Cardiology recommends empagliflozin as preferred SGLT2 inhibitor for adults with type 2 diabetes and established cardiovascular disease in new Expert Consensus Decision Pathway
A new Expert Consensus Decision Pathway issued by the American College of Cardiology (ACC) recommends empagliflozin as the preferred SGLT2 inhibitor for its proven benefit in reducing the risk of cardiovascular death in adults with type 2 diabetes and established cardiovascular disease. The recommendation, part of the ACC’s first Expert Consensus Decision Pathway on novel therapies for cardiovascular risk reduction in adults with type 2 diabetes, was released today and published online in the Journal of the American College of Cardiology.1 Empagliflozin is marketed by Boehringer Ingelheim and Eli Lilly and Company (NYSE: LLY).
This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20181126005751/en/
The recommendation of empagliflozin is based on evidence from the landmark EMPA-REG OUTCOME® trial, which investigated the effects of empagliflozin compared with placebo when added to standard of care in adults with type 2 diabetes and established cardiovascular disease.2 In addition to the ACC Expert Consensus Decision Pathway, the American Diabetes Association® (ADA) and European Association for the Study of Diabetes (EASD) recently published a Consensus Report recommending SGLT2 inhibitors, such as empagliflozin, to help manage cardiovascular outcomes in patients with type 2 diabetes.3 Empagliflozin is also the only SGLT2 inhibitor recommended in the ADA 2018 Standards of Medical Care in Diabetes for reducing the risk of cardiovascular death in people with type 2 diabetes and established cardiovascular disease.4 Worldwide, more than 50 treatment guidelines have been updated to include findings from the EMPA-REG OUTCOME trial® in their endorsement of type 2 diabetes treatments with proven cardiovascular benefits.5
“People with type 2 diabetes are at increased risk of serious cardiovascular complications and events, even when their blood sugar is under control, which is why a focus on reducing cardiovascular risk in people with diabetes is critical,” said Waheed Jamal, M.D., Corporate Vice President and Head of CardioMetabolic Medicine, Boehringer Ingelheim. “The ACC Expert Consensus Decision Pathway, along with the Consensus Report from the ADA and EASD, all now recommend that comprehensive cardiovascular care for adults with type 2 diabetes and established cardiovascular disease includes a treatment shown to improve cardiovascular outcomes in this population, such as empagliflozin. These recommendations reflect a fundamental shift in the management of type 2 diabetes, moving beyond glucose control to a broader strategy of comprehensive cardiovascular risk reduction.”
The 2018 ACC Expert Consensus Decision Pathway emphasises the need for a collaborative treatment approach by healthcare providers to reduce cardiovascular risk and improve survival in people with type 2 diabetes, a growing public health epidemic.1 People with diabetes are up to four times more likely to develop cardiovascular disease than those without diabetes, and cardiovascular disease is the leading cause of death associated with diabetes.6,7
The ACC Expert Consensus Decision Pathway’s recommendation of empagliflozin, along with those of the ADA and EASD, represents a shift towards a comprehensive and team-based approach for managing the overall health of people with type 2 diabetes. The ACC encourages cardiologists to work as part of a broad healthcare provider team including primary care, internal medicine and endocrinology physicians, as well as nurse practitioners, physician assistants, diabetes educators and pharmacists, to improve the care and outcomes of people with type 2 diabetes.1
“The EMPA-REG OUTCOME trial® ushered in a new era for managing type 2 diabetes. Now, cardiovascular risk reduction is prioritised as a primary goal of diabetes management,” said Sherry Martin, M.D., Vice President, Medical Affairs, Lilly. “With the adoption of the ACC’s Expert Consensus Decision Pathway and ADA-EASD Consensus Report, the cardiology community will have an important role as part of the healthcare team managing cardiovascular risk in people with type 2 diabetes.”
About EMPA-REG OUTCOME
EMPA-REG OUTCOME® was a long-term, multicenter, randomised, double-blind, placebo-controlled trial of more than 7,000 patients from 42 countries with type 2 diabetes and established cardiovascular disease.
The study assessed the effect of empagliflozin (10 mg or 25 mg once daily) added to standard of care compared with placebo added to standard of care. Standard of care was comprised of glucose-lowering agents and cardiovascular drugs (including for blood pressure and cholesterol). The primary endpoint was defined as time to first occurrence of cardiovascular death, non-fatal heart attack or non-fatal stroke.
The overall safety profile of empagliflozin was consistent with that of previous trials.
About Diabetes and Cardiovascular Disease
More than 425 million people worldwide have diabetes, of which over 212 million are estimated to be undiagnosed.8 By 2045, the number of people with diabetes is expected to rise to 629 million people worldwide.8 Type 2 diabetes is the most common form of diabetes, responsible for around 90 percent of diabetes cases in high-income countries.8 Diabetes is a chronic condition that occurs when the body either does not properly produce, or use, the hormone insulin.8
Due to the complications associated with diabetes, such as high blood sugar, high blood pressure and obesity, cardiovascular disease is a major complication and the leading cause of death associated with diabetes.9,10 People with diabetes are two to four times more likely to develop cardiovascular disease than people without diabetes.10 In 2017, diabetes caused four million deaths worldwide, with cardiovascular disease as the leading cause.8 Approximately 50 percent of deaths in people with type 2 diabetes worldwide are caused by cardiovascular disease.7,11
Having a history of diabetes at age 60 can shorten a person’s life span by as much as six years compared with someone without diabetes. And having both diabetes and a history of heart attack or stroke by age 60 can shorten a person’s life span by as much as 12 years compared with someone without these conditions.12
More than 50 guidelines have been updated to endorse type 2 diabetes agents with proven cardiovascular benefits since 2016, including a recent Consensus Report initiated by the American Diabetes Association® and European Association for the Study of Diabetes, recommending that, in patients with type 2 diabetes and established atherosclerotic cardiovascular disease, SGLT2 inhibitors (such as empagliflozin) or GLP1 receptor agonists with proven cardiovascular benefits are recommended as part of glycaemic management.13,14
Empagliflozin (marketed as Jardiance®) is an oral, once daily, highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor and the first type 2 diabetes medicine to include cardiovascular death risk reduction data in the label in several countries.15,16,17
Inhibition of SGLT2 with empagliflozin in people with type 2 diabetes and high blood sugar levels leads to excretion of excess sugar in the urine. In addition, initiation of empagliflozin increases excretion of salt from the body and reduces the fluid load of the body’s blood vessel system (i.e. intravascular volume). Empagliflozin induces changes to the sugar, salt and water metabolism in the body that may contribute to the reductions in cardiovascular death observed in the EMPA-REG OUTCOME® trial.
Please click on the following link for ‘Notes to Editors’ and ‘References’: http://www.boehringer-ingelheim.com/press-release/empa-acc-expert-consensus-decision-pathway
Dr Petra Kienle
Product Communication Manager
Phone: +49 (6132) 77 143877
Director of Communications
Lilly Diabetes and Lilly USA
Phone: +1 (317) 432-5195
Om Business Wire
(c) 2018 Business Wire, Inc., All rights reserved.
Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.
Følg saker fra Business Wire
Registrer deg med din epostadresse under for å få de nyeste sakene fra Business Wire på epost fortløpende. Du kan melde deg av når som helst.
Siste saker fra Business Wire
Novostia Technology for Heart Valve Prosthesis Raises CHF 6.5 Million to Start First Clinical Trials22.2.2019 07:30:00 | Pressemelding
Novostia announces that it raised CHF 6.5 million from private investors to advance its disruptive aortic and mitral heart valve to clinical trials. Heart valve diseases affect more than 100 million people worldwide. Every year hundreds of thousands of patients undergo a heart valve replacement. Available technologies entail serious constraints: lifelong anticoagulant medication or further replacements due to limited valve durability. Thanks to a unique patented design and the use of a high-performance biocompatible polymer, Novostia eliminates all these constraints as well as clicking noises. “Our technology should significantly improve the quality of life of people bearing a heart valve prosthesis, especially kids and young patients, while reducing overall healthcare costs. We appreciate the trust and support of our investors and look forward to bringing this long-awaited innovation to the patients and the physicians,” said Geoffroy Lapeyre, Novostia CEO. About Novostia Novostia is a
Blue Danube Systems Coherent Massive MIMO Delivers Industry’s Highest Capacity Gains in Multiple Commercial Networks21.2.2019 23:00:00 | Pressemelding
Blue Danube Systems, a provider of intelligent wireless access solutions that help mobile operators address the challenge of explosive data growth, is today announcing significant results from multiple new FDD deployments in commercial networks with live traffic. These multi-unit installations show more than 2.5 times higher cellular capacity and significantly increased user throughputs for both legacy LTE terminals as well as new generation smartphones. Blue Danube’s BeamCraft™ 500 antennas were deployed in 4G LTE networks in dense urban megacities and other areas with high traffic load nearing full bandwidth utilization. The systems exploited intelligent analytics-based multi-site optimization, and the performance was measured directly from the operators’ network performance management systems. The results exhibit increasing gains with the number of units deployed and highlight the benefits of multi-site optimization and coordination. Consistent performance improvements were observed
Blue Danube Systems Expands Operations in India and Welcomes Sundeep Raina to the Global Sales Management Team21.2.2019 22:00:00 | Pressemelding
Blue Danube Systems, a provider of intelligent wireless access solutions that help mobile operators address the challenge of explosive data growth, is announcing that Sundeep Raina has joined the company as the Country Sales Director of India. Mr. Raina joins Blue Danube with over 19 years of industry experience in telecommunications equipment sales and key account management most recently with ZTE Corporation and previously at Ericsson India. Mr. Raina will be responsible for developing new business relationships, managing current engagements and sales expansion in India. He will be based in Mumbai close to Blue Danube’s customers and partners. “We are excited to have Sundeep on board and look forward to Blue Danube’s continued progress in India,” said John Shelnutt, Blue Danube’s Vice President of Sales. “With the recent positive developments and increasing interest towards our solutions we decided to increase our presence in India to better serve our key customers. Sundeep has demon
Blue Danube Systems Enhances BeamPlanner™ Software Including Artificial Intelligence and Machine Learning Capabilities21.2.2019 20:00:00 | Pressemelding
Blue Danube Systems, a provider of intelligent wireless access solutions that help mobile operators address the challenge of explosive data growth, is today announcing new capabilities into its BeamPlanner™ cloud software suite. BeamPlanner is the world’s first network planning and optimization tool for beamforming antenna systems. With the new and enhanced artificial intelligence (AI) and machine learning (ML) functionalities, BeamPlanner becomes the automated platform for network-wide operation of Blue Danube’s Coherent Massive MIMO systems. BeamPlanner utilizes an intelligent analytics-based, data-driven multi-site optimization engine that now has been enhanced with 3D ray tracing capabilities for improved prediction results accuracy. The simulation platform provides actionable beamforming recommendations and expected capacity results matching the real-world performance results validated through drive tests, network statistics data and standard key performance indicators (KPIs). In
Recipients of HCL GRANT 2019 Felicitated by Amitabh Kant & Sourav Ganguly21.2.2019 19:06:00 | Pressemelding
Mr. Amitabh Kant, CEO, Niti Aayog and Mr. Sourav Ganguly, Former captain of the Indian National Cricket Team felicitated the winners of HCL Grant 2019 at a ceremony held today at HCL Technologies Campus, Noida, in the presence of Mr. Shiv Nadar, Founder & Chairman, HCL, Ms. Roshni Nadar Malhotra, Vice Chairperson, HCL Technologies and Chairperson, CSR Committee, HCL Technologies, along with senior dignitaries, bureaucrats, NGO-partners and the HCL leadership. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20190221005822/en/ L to R - Ms. Roshni Nadar Malhotra, Vice Chairperson, HCL Technologies and Chairperson, CSR Committee, HCL Technologies; Mr. Sourav Ganguly, Former Captain of Indian National Cricket Team; Mr. Amitabh Kant, CEO, NITI Aayog and Ms. Robin Abrams, former president of Palm Computing and longest-serving Board member of HCL Technologies along with the HCL Grant 2019 recipients - Environment - Wildlife Trust of In
International Indigenous Languages Conference Set for June in British Columbia21.2.2019 17:48:00 | Pressemelding
In celebration of the United Nations 2019 International Year of Indigenous Languages, the First Peoples’ Cultural Foundation (FPCF) and the First Peoples’ Cultural Council (FPCC), in partnership with the Canadian Commission for UNESCO, will host a major international conference on Indigenous language revitalization in British Columbia this summer. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20190221005758/en/ WHAT: The HELISET TŦE SḰÁL – ‘Let the Languages Live’ – 2019 International Conference on Indigenous Languages will bring together Indigenous leaders and language experts, speakers, learners and advocates from around the globe to celebrate, honour and share expertise in Indigenous language reclamation, revitalization and maintenance and to learn about successful language projects in B.C. The goal of the conference is to provide participants with practical skills and knowledge to support the Indigenous language revitaliz