GlobeNewswire

Abeona Therapeutics Reports Preclinical Data Demonstrating Broad Therapeutic Potential of AIM™ Gene Therapy in Retinal Diseases at Association for Research in Vision and Ophthalmology Annual Meeting

Del

NEW YORK and CLEVELAND, May 01, 2019 (GLOBE NEWSWIRE) -- Abeona Therapeutics Inc. (Nasdaq: ABEO), a fully-integrated leader in gene and cell therapy, today announced that intravitreal administration of the Company’s novel AIM™ AAV204 capsid to non-human primates led to robust transgene expression in the inner and outer retina. These new preclinical data also support the potential use of intravitreal administration to deliver gene therapy in an out-patient setting for a wide range of inherited and acquired retinal diseases. Findings were presented at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting in Vancouver.

“The broad retinal tropism of the AIM™ AAV204 capsid in non-human primates underscores the potential of our platform to deliver gene therapy beyond inherited diseases, including treatment of acquired retinal disorders that may be currently underserved,” said Timothy J. Miller, Ph.D., President and Chief Scientific Officer. “Intravitreal administration of AAV gene therapy, which does not require surgery, could potentially be performed in an out-patient setting and may be a safer and less invasive approach.”

In the preclinical study, intravitreal administration of the novel AIM™ AAV204 capsid in non-human primates resulted in broad transgene expression in the peripheral retina as well as intense expression in the fovea 25 days post-administration. AAV204 also transduced photoreceptor cells in retinal explants and transduced the outer retina, with positive green fluorescent protein (GFP) expression.

The non-human primate data were complemented by findings from mice models, which identified AAV204 as one of three lead candidate AIM™ capsids that demonstrate robust transduction of retinal cells. The data in mice demonstrated that intravitreal administration resulted in broad retinal expression of AAV204 that penetrated to the photoreceptor and retinal pigmented epithelium (RPE) layers.

About the AIM™ Vector Platform
Abeona is developing the AIM™ Vector Platform: a next generation of adeno-associated virus (AAV) capsids for use in gene therapies. The AIM™ capsid library can utilize AAV biology to selectively target delivery of genetic payloads to the central nervous system, lungs, eye, muscle, liver and other tissues. AIM™ vectors are non-virus-producing and have shown the potential to evade the immune responses generated by exposure to naturally-occurring AAV vectors. The Company’s AIM™ library contains more than 100 capsids with tissue tropisms selected for their potential to target a wide range of organs and multiple routes of delivery.

About Abeona Therapeutics
Abeona Therapeutics Inc. is a clinical-stage biopharmaceutical company developing gene and cell therapies for serious diseases. The Company’s clinical programs include EB-101, its autologous, gene-corrected cell therapy for recessive dystrophic epidermolysis bullosa, as well as ABO-102 and ABO-101, novel AAV9-based gene therapies for Sanfilippo syndrome types A and B (MPS IIIA and MPS IIIB). The Company’s portfolio of AAV9-based gene therapies also features ABO-202 and ABO-201 for CLN1 disease and CLN3 disease, respectively. Its preclinical assets include ABO-401, which uses the novel AIM™ AAV vector platform to address all mutations of cystic fibrosis. Abeona has received numerous regulatory designations from the FDA and EMA for its pipeline candidates and is the only company with Regenerative Medicine Advanced Therapy designation for two investigational therapies (EB-101 and ABO-102). For more information, visit www.abeonatherapeutics.com.

Forward Looking Statement
This press release contains certain statements that are forward-looking within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and that involve risks and uncertainties.  These statements include statements regarding our pipeline including the potential for the AIM™ vector platform in the treatment of retinal diseases based upon pre-clinical data, and the company’s goals and objectives.  We have attempted to identify forward looking statements by such terminology as “may,” will,” “anticipate,” “believe,” “estimate,” “expect,” “intend,” and similar expressions.

Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, numerous risks and uncertainties, including but not limited to: continued interest in our rare disease portfolio, our ability to initiate and enroll patients in clinical trials, the impact of competition, the ability to secure licenses for any technology that may be necessary to commercialize our products, the ability to achieve or obtain necessary regulatory approvals, the impact of changes in the financial markets and global economic conditions, risks associated with data analysis and reporting, and other risks as may be detailed from time to time in the Company’s annual reports on Form 10-K and quarterly reports on Form 10-Q and other reports filed by the Company with the Securities and Exchange Commission.  The Company undertakes no obligation to revise the forward-looking statements or update them to reflect events or circumstances occurring after the date of this presentation, whether as a result of new information, future developments or otherwise, except as required by the federal securities laws.

Investor Contact:
Sofia Warner
Senior Director, Investor Relations
Abeona Therapeutics
+1 (646) 813-4710
swarner@abeonatherapeutics.com

Media Contact:
Scott Santiamo
Director, Corporate Communications
Abeona Therapeutics
+1 (718) 344-5843
ssantiamo@abeonatherapeutics.com

Om GlobeNewswire

GlobeNewswire
GlobeNewswire
One Liberty Plaza - 165 Broadway
NY 10006 New York

https://globenewswire.com

GlobeNewswire is one of the world's largest newswire distribution networks, specializing in the delivery of corporate press releases financial disclosures and multimedia content to the media, investment community, individual investors and the general public.

Følg saker fra GlobeNewswire

Registrer deg med din epostadresse under for å få de nyeste sakene fra GlobeNewswire på epost fortløpende. Du kan melde deg av når som helst.

Siste saker fra GlobeNewswire

Fortuna CEO purchases company shares17.5.2019 21:00:00 CESTPressemelding

VANCOUVER, British Columbia, May 17, 2019 (GLOBE NEWSWIRE) -- Fortuna Silver Mines Inc. (NYSE: FSM) (TSX: FVI) reports that Jorge A. Ganoza, Chief Executive Officer of the Company, has increased his equity position in the Company by acquiring 170,000 common shares on the open market at an average price of US$2.59 per share. An insider report filing reflecting the share acquisition has been made on the SEDI website at www.sedi.ca. About Fortuna Silver Mines Inc. Fortuna is a growth oriented, precious metal producer with its primary assets being the Caylloma silver mine in southern Peru, the San Jose silver-gold mine in Mexico and the Lindero gold Project, currently under construction, in Argentina. The Company is selectively pursuing acquisition opportunities throughout the Americas and in select other areas. For more information, please visit its website at www.fortunasilver.com. ON BEHALF OF THE COMPANY Carlos Baca Investor Relations Manager Trading symbols: NYSE: FSM | TSX: FVI Inves

Oxford Immunotec Welcomes Updated CDC Recommendations for Tuberculosis Screening and Testing of Healthcare Personnel17.5.2019 15:25:00 CESTPressemelding

OXFORD, United Kingdom and MARLBOROUGH, Mass., May 17, 2019 (GLOBE NEWSWIRE) -- Oxford Immunotec Global PLC (Nasdaq:OXFD) (the "Company"), a global, high-growth diagnostics company, today announced that it welcomes the updated Tuberculosis Screening, Testing, and Treatment of U.S. Health Care Personnel: Recommendations from the National Tuberculosis Controllers Association and CDC, 2019, published by the U.S. Centers for Disease Control and Prevention (CDC)1. These guidelines increase the focus on eradicating tuberculosis (TB) disease in the United States through an individual risk-based approach to screening and treatment for Healthcare Personnel (HCP). Key highlights from the updated guidelines include: Recommendation for TB Screening and Individual Based TB Risk Assessment on Hire : continue baseline screening of all HCPs upon hire with the addition of an individual risk assessment Recommendation to Focus Serial Testing on Higher Risk Individuals: decision to perform TB testing afte

First Dolby Cinema Opens in Germany with Kinopolis Gruppe in Munich17.5.2019 14:30:00 CESTPressemelding

MUNICH, Germany, May 17, 2019 (GLOBE NEWSWIRE) -- Dolby Laboratories, Inc. (NYSE:DLB) and Kinopolis Gruppe today announced the opening of the first Dolby Cinema in Germany at the renowned Mathäser Palast in Munich. Film fans can now enjoy the very best cinema presentation in the heart of the city, following the opening of the highly-anticipated site. Dolby Cinema combines Dolby Vision, Dolby Atmos, and bespoke design to create the perfect environment to be fully immersed in the storytelling of a film. Dolby Vision is presented through a dual 4K laser, High Dynamic Range (HDR) projector system, and boasts a spectacular, ultra vivid picture. Compared to standard screens, the Dolby Vision image is twice as bright, 500 times the contrast ratio, has blacker blacks, and an unsurpassed colour palette. Cutting-edge Dolby Atmos sound transports viewers into the scene, filling the cinema with a soundscape that flows all around and above the audience. Dolby works with each cinema location to crea

Four Progressive Leaders to Receive the 2019 YPO Global Innovation Awards  17.5.2019 08:00:00 CESTPressemelding

Thirst CEO Mina Guli, RaySearch Laboratories AB CEO Johan Löf, Malwarebytes CEO Marcin Kleczynski & Apeel CEO James Rogers honored NEW YORK, May 17, 2019 (GLOBE NEWSWIRE) -- YPO, the premier global leadership organization for more than 27,000 chief executives, today announced the winners of its prestigious Global Innovation Awards. Presented in conjunction with YPO Innovation Week, the Global Innovation Awards annually recognizes YPO members who are making an impact through transformation around the globe in four categories: Social Impact, Medical, Technology, and Manufacturing. “Our goal for the 2019 Global Innovation Award winners is to recognize YPO member companies that are creating scalable solutions which address challenges both at a local and/or global level,” said Mohamed Alkady, YPO Global Innovation Awards Chair. “Each of these winners represent their category with glaring leadership and, most importantly, a clear mission and vision. This extraordinary group have demonstrated

Dr. Deep Saini appointed as Dalhousie University’s 12th President16.5.2019 21:09:00 CESTPressemelding

Halifax, NS, May 16, 2019 (GLOBE NEWSWIRE) -- Dalhousie University’s Board of Governors announced today that Dr. Deep Saini has been appointed as the university’s 12th President and Vice-Chancellor. Dr. Saini, who is currently Vice-Chancellor and President of the University of Canberra in Australia, was the unanimous choice of the search committee. He is an accomplished leader who combines significant Canadian post-secondary experience with a global outlook; a distinguished scientist whose belief in the transformative power of education has defined his life’s journey; and a warm, genuine and inspiring individual ready to build on Dal’s 200 years of achievement and chart a course towards even greater success in our third century ahead. “I am honoured and humbled by the opportunity to serve as the 12th President and Vice-Chancellor of Dalhousie University,” says Dr. Saini. “The university’s singular commitment to its anchor role in the region’s economic and social development is fittingl

PureCircle and Merisant Renew Stevia Supply Agreement16.5.2019 18:00:00 CESTPressemelding

Leading Tabletop Sweetener Company Will Increase Its Purchases of Great-Tasting Ingredients From Top Global Stevia Supplier CHICAGO, May 16, 2019 (GLOBE NEWSWIRE) -- PureCircle (LSE: PURE), the world’s leading producer and innovator of stevia sweeteners, has entered into a new stevia supply agreement with Merisant, one of the world’s leading producers of low- and zero-calorie tabletop sweeteners for consumers. This new and expanded partnership will help to ensure Merisant’s long-term supply of the best-tasting stevia ingredients. Merisant has been a partner and customer of PureCircle for the last ten years. Merisant’s sweetener products are sold in more than 90 countries worldwide. This new agreement focuses on the supply to Merisant of PureCircle’s next generation stevia sweetener ingredients like Reb M. PureCircle announced last year that it significantly increased its capacity to supply Reb M to consumer product companies. PureCircle’s Reb M is a next generation zero-calorie sweeten